2-N(2-hydroxy-3-chloro-1-naphthyl)pyridine-2,5-dicarboxamide | 1443619-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-N(2-hydroxy-3-chloro-1-naphthyl)pyridine-2,5-dicarboxamide
• 英文别名: 2-N-(3-chloro-2-hydroxynaphthalen-1-yl)pyridine-2,5-dicarboxamide
• CAS: 1443619-47-3
• 化学式: C₁₇H₁₂ClN₃O₃
• 分子量: 341.754
• InChiKey: LYBMAQZMCWZTIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• NOVEL HETEROCYCLIC COMPOUNDS USEFUL IN SIRTUIN BINDING AND MODULATION
  申请人：SMB Innovation

  公开号：US20140329854A1

  公开（公告）日：2014-11-06

  Provided are novel heterocyclic sirtuin binding agents, e.g., N-aryl substituted pyridine dicarboxamides, which are useful as sirtuin modulators. Also provided are methods of using the pyridine dicarboxamide compounds for treating sirtuin mediated disorders and conditions, such as diabetes, cancers, and obesity and diseases related to aging.