2-<2-Hydroxy-phenylimino>-indan-1,3-dion | 17438-22-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-<2-Hydroxy-phenylimino>-indan-1,3-dion
• 英文别名: 2-[(2-hydroxyphenyl)imino]-1H-indene-1,3(2H)-dione；2-(2-hydroxyphenyl)iminoindene-1,3-dione
• CAS: 17438-22-1
• 化学式: C₁₅H₉NO₃
• mdl: MFCD01461835
• 分子量: 251.241
• InChiKey: LEVUICRLFJDCDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Dérivés d'indane-1, 3-dione et d'indane-1,2,3-trione, leurs procédés de préparation et leur application en thérapeutique
  申请人：INNOTHERA

  公开号：EP0566446A1

  公开（公告）日：1993-10-20

  Composés utiles en thérapeutique de formule : dans laquelle R₂ et R₃ représentent indépendamment l'un de l'autre H, alkoxy en C₁-C₄ ou OH et (A, B) = (oxygène, oxygène) auquel cas l'un parmi R et R₁ représente OH, halogène, amino secondaire ou amine tertiaire et l'autre représente NHCOR₄, NHNHCOR₅ ou NHNHCOCONH₂ ou bien R et R₁ forment ensemble =N-NH-CO-R'₅, =N-NH-CO-CO-NH₂, = N-NH-R₆, =N-R₇, =N-O-CO-R₈ ou = C(CH₃)-NH-NH-CO-R₉ ; ou (A, B) = (N-NH-CX-NHR₁₀, oxygène) auquel cas R et R₁ forment ensemble =N-OH.

  可用于配方治疗的化合物 ： 其中 R₂ 和 R₃ 各自独立地代表 H、C₁-C₄ 烷氧基或 OH 以及 (A, B) = (氧, 氧)，在这种情况下，R 和 R₁ 中的一个代表 OH、卤素、仲胺或叔胺，另一个代表 NHCOR₄、NHNHCOR₅ 或 NHNHCOCONH₂ 或 R 和 R₁ 共同形成 =N-NH-CO-R'₅、=N-NH-CO-CO-NH₂、=N-NH-R₆、=N-R₇、=N-O-CO-R₈ 或 = C(CH₃)-NH-NH-CO-R₉ ；或（A，B）＝（N-NH-CX-NHR₁₀，氧），在这种情况下，R 和 R₁ 共同形成＝N-OH。
• Microrna modulators and method for identifying and using the same
  申请人：Huang Qihong

  公开号：US20100196357A1

  公开（公告）日：2010-08-05

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying And Using The Same
  申请人：Huang Qihong

  公开号：US20120010177A1

  公开（公告）日：2012-01-12

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying and Using the Same
  申请人：Huang Qihong

  公开号：US20130023498A1

  公开（公告）日：2013-01-24

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• US20140255386A1
  申请人：——

  公开号：US20140255386A1

  公开（公告）日：2014-09-11