1,7-Naphthyridine-8-carboxylic acid | 1060816-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,7-Naphthyridine-8-carboxylic acid
• CAS: 1060816-77-4
• 化学式: C₉H₆N₂O₂
• 分子量: 174.16
• InChiKey: ZCJYCEANCAHRKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL TRIPEPTIDE COMPOUNDS AND ANTI-AIDS DRUGS
  申请人：JAPAN ENERGY CORPORATION

  公开号：EP0900566A1

  公开（公告）日：1999-03-10

  A novel tripeptide compound represented by the following general formula (I) exhibiting superior HIV protease inhibition activity, and an anti-AIDS medicine comprising this compound as an effective component and a pharmaceutically acceptable salt thereof. (R)-N-(2-methylbenzyl)-3-(2S,3S)-3-[N-(2-chromonecarbonyl)-L-asparaginyl]amino-2-hydroxy-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide can be given as a typical example of this compound.

  一种由以下通式(I)代表的新型三肽化合物，具有优异的抑制HIV蛋白酶活性，以及一种以该化合物为有效成分的抗艾滋病药物及其药学上可接受的盐。 (R)-N-(2-甲基苄基)-3-(2S,3S)-3-[N-(2-铬羰基)-L-天冬酰胺基]氨基-2-羟基-4-苯基丁酰基}-5,5-二甲基-1,3-噻唑烷-4-甲酰胺可作为该化合物的典型实例。
• BENZONAPHTHYRIDINE-CONTAINING VACCINES
  申请人：Novartis AG

  公开号：EP2440245A1

  公开（公告）日：2012-04-18
• HOMOGENEOUS SUSPENSION OF IMMUNOPOTENTIATING COMPOUNDS AND USES THEREOF
  申请人：Novartis AG

  公开号：EP2512478A1

  公开（公告）日：2012-10-24
• US6291432B1
  申请人：——

  公开号：US6291432B1

  公开（公告）日：2001-09-18
• [EN] BENZONAPHTHYRIDINE-CONTAINING VACCINES<br/>[FR] VACCINS CONTENANT DE LA BENZONAPHTYRIDINE
  申请人：NOVARTIS AG

  公开号：WO2010144734A1

  公开（公告）日：2010-12-16

  The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.