tetrachloro(dipyrido[3,2-a:2',3'-c]phenazine)ruthenium(IV) | 224156-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: tetrachloro(dipyrido[3,2-a:2',3'-c]phenazine)ruthenium(IV)
• 英文别名: quinoxalino[2,3-f][1,10]phenanthroline;tetrachlororuthenium
• CAS: 224156-00-7
• 化学式: C₁₈H₁₀Cl₄N₄Ru
• 分子量: 525.186
• InChiKey: TYOWOLMXBWJDIY-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  4,4′-bithiazole 、 tetrachloro(dipyrido[3,2-a:2',3'-c]phenazine)ruthenium(IV) 、 高氯酸盐 、 乙腈 以 乙二醇 为溶剂， 生成 di(4,4'-bithiazole)(dipyrido[3,2-a:2',3'-c]phenazine)ruthenium(II) perchlorate-acetonitrile (1/1)
  参考文献：
  名称：

  Single oxygen-mediated DNA photocleavage of a di-bithiazolyl ruthenium(II) complex [Ru(btz)2(dppz)]2+

  摘要：

  A novel di-bithiazolyl ruthenium(II) complex [Ru(btz)(2)(dppz)](2+) (btz = 4,4'-bithiazole; dppz = dipyrido[3,2-a:2',3'-c]phenazine) has been synthesized and characterized. The DNA binding behaviors of this complex have been studied by spectroscopic and viscosity measurements. Results suggest that the complex binds to CT DNA via an intercalative mode. Upon irradiation at 365 nm, this complex was found to promote the cleavage of plasmid pBR322 DNA from supercoiled form I to nicked form II. The mechanism studies reveal that singlet oxygen O-1(2) plays a significant role in the photocleavage. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2008.02.008