| 1246377-59-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• CAS: 1246377-59-2
• 化学式: C₈H₆F₉NO
• 分子量: 303.127
• InChiKey: HKLMXYFRSSHKPX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 bis(norbornadiene)rhodium(l)tetrafluoroborate 、 双(二苯基膦)丁烷 、 氢气 作用下， 以 二氯甲烷 为溶剂， 20.0 ℃ 、3.55 MPa 条件下， 反应 20.0h， 以96%的产率得到N-[(2S)-3,3,4,4,5,5,6,6,6-nonafluorohexan-2-yl]acetamide
  参考文献：
  名称：

  Highly enantioselective synthesis of α-(perfluoroalkyl)amines via hydrogenation of enamide precursors in the presence of chiraphos-rhodium catalyst

  摘要：

  Highly (up to 99% ee) enantio-enriched perfluoroalkyl amines can be synthesized by the perfluoroalkylation of nitriles with Lewis acidic perfluoroalkyl titanate reagents and catalytic asymmetric hydrogenation with the chiraphos-Rh catalyst of the resultant perfluoroalkyl enamides via base-mediated tautomerization. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.05.021
• 作为产物：
  描述：

  、 乙酸酐 以 乙醚 为溶剂， 生成
  参考文献：
  名称：

  Highly enantioselective synthesis of α-(perfluoroalkyl)amines via hydrogenation of enamide precursors in the presence of chiraphos-rhodium catalyst

  摘要：

  Highly (up to 99% ee) enantio-enriched perfluoroalkyl amines can be synthesized by the perfluoroalkylation of nitriles with Lewis acidic perfluoroalkyl titanate reagents and catalytic asymmetric hydrogenation with the chiraphos-Rh catalyst of the resultant perfluoroalkyl enamides via base-mediated tautomerization. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.05.021