[3-(2-naphthyl)-5-eth-(E)-ylidene-6-oxo-4-prop-2-en-(E)-ylidene-5,6-dihydro-4H-pyridazin-1-yl]propylacetic acid | 1207683-94-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: [3-(2-naphthyl)-5-eth-(E)-ylidene-6-oxo-4-prop-2-en-(E)-ylidene-5,6-dihydro-4H-pyridazin-1-yl]propylacetic acid
• 英文别名: 2-[4-(naphthalen-1-ylmethyl)-1-oxophthalazin-2(1H)-yl]pentanoic acid；US8969348, 2-[4-(Naphthalen-1-ylmethyl)-1-oxophthalazin-2(1H)-yl]pentanoic acid；2-[4-(naphthalen-1-ylmethyl)-1-oxophthalazin-2-yl]pentanoic acid
• CAS: 1207683-94-0
• 化学式: C₂₄H₂₂N₂O₃
• 分子量: 386.45
• InChiKey: KOFDKPAWXNMYGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CHYMASE INHIBITORS
  申请人：Abeywardane Asitha

  公开号：US20120129863A1

  公开（公告）日：2012-05-24

  Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase. Also disclosed are pharmaceutical compositions, methods of using and making the same.

  本发明涉及小分子抑制剂，用于治疗涉及chymase的各种疾病和病状。同时还揭示了制药组合物、使用和制备方法。
• US8969348B2
  申请人：——

  公开号：US8969348B2

  公开（公告）日：2015-03-03
• [EN] CHYMASE INHIBITORS<br/>[FR] INHIBITEURS DE CHYMASE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010019417A2

  公开（公告）日：2010-02-18

  Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase (formula I). Also disclosed are pharmaceutical compositions, methods of using and making the same.