2-{6-[1-ethyl-3-(4-trifluoromethoxyphenyl)ureido]-3-methyl-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid | 685832-16-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-{6-[1-ethyl-3-(4-trifluoromethoxyphenyl)ureido]-3-methyl-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid
• 英文别名: 2-[[6-[Ethyl-[[4-(trifluoromethoxy)phenyl]carbamoyl]amino]-3-methyl-5,6,7,8-tetrahydronaphthalen-2-yl]sulfanyl]-2-methylpropanoic acid
• CAS: 685832-16-0
• 化学式: C₂₅H₂₉F₃N₂O₄S
• 分子量: 510.577
• InChiKey: QISONWUFJILVNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] TETRAHYDROPYRAN COMPOUNDS AS TACHYKININ ANTAGONISTS<br/>[FR] COMPOSES DE TETRAHYDROPYRANE SERVANT D'ANTAGONISTES DE TACHYKININE
  申请人：MERCK SHARP & DOHME

  公开号：WO2004078750A1

  公开（公告）日：2004-09-16

  The present invention relates to the compounds of the formula (I), wherein R?1, R2, R3, R4, R5, R6, R7, R8, R9¿ and W are as defined herein, and pharmaceutically acceptable salts thereof; the compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

  本发明涉及公式（I）中的化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9和W如本文所定义，并且其药学上可接受的盐；这些化合物在治疗或预防抑郁症、焦虑、疼痛、炎症、偏头痛、呕吐或带状疱疹后神经痛方面特别有用。
• [EN] SUBSTITUTED TETRALINS AND INDANES AND THEIR USE<br/>[FR] TETRALINES ET INDANES SUBSTITUES ET LEUR UTILISATION
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2004037779A1

  公开（公告）日：2004-05-06

  This invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.

  这项发明涉及四氢萘和茚烷化合物，含有它们的组合物，以及将它们用作PPARα调节剂来治疗或抑制例如糖尿病等疾病进展的方法。
• [EN] SUBSTITUTED TETRALINS AND INDANES<br/>[FR] TETRALINES ET INDANES SUBSTITUES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2004037778A1

  公开（公告）日：2004-05-06

  The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, dyslipidemia.

  这项发明涉及四氢萘和茚烷化合物，含有它们的组合物，以及将它们用作PPARα调节剂来治疗或抑制例如脂质代谢异常等疾病进展的方法。
• [EN] TREATING SYNDROME X WITH SUBSTITUTED TETRALINS AND INDANES<br/>[FR] TRAITEMENT DU SYNDROME X A L'AIDE DE TETRALINES ET D'INDANES SUBSTITUES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2004037777A1

  公开（公告）日：2004-05-06

  The invention features tetralin and indane compounds of Formula I, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.

  该发明涉及公式I的四氢萘和茚烷化合物，包含它们的组合物，以及将它们用作PPARα调节剂治疗或抑制糖尿病等疾病进展的方法。
• Process for the preparation of substituted tetralin and substituted indane derivatives
  申请人：Zhang-Plasket Fan

  公开号：US20050240049A1

  公开（公告）日：2005-10-27

  The present invention relates to novel processes for the preparation of substituted tetralin. and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.

  本发明涉及一种制备取代四氢萘和取代茚衍生物的新工艺。本发明还涉及一种用于制备取代四氢萘和取代茚衍生物中间体的新工艺。