N-(3-Methyl-1H-pyrazol-4-yl)acetamide | 1904-25-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(3-Methyl-1H-pyrazol-4-yl)acetamide
• 英文别名: N-(5-methyl-1H-pyrazol-4-yl)acetamide
• CAS: 1904-25-2
• 化学式: C₆H₉N₃O
• 分子量: 139.16
• InChiKey: IMKJZFWLFJLZFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• 4-AMINO-5-METHYLPYRAZOLE DERIVATIVES AND PROCESS FOR PRODUCTION THEREOF
  申请人：Sankyo Agro Company, Limited

  公开号：EP1580189A1

  公开（公告）日：2005-09-28

  The present invention relates to 4-amino-5-methylpyrazole derivatives represented by the following formula (I): (wherein R1 represents an isobutyl group, a cyclobutylmethyl group, a neopentyl group or the like) or a salt thereof, which are novel compounds being useful as synthetic intermediates of pharmaceuticals, agricultural chemicals or the like.

  本发明涉及以下式(I)所表示的4-氨基-5-甲基吡唑衍生物（其中R1表示异丁基基团、环丁基甲基基团、新戊基基团或类似物）或其盐，这些新化合物可用作药物、农药或类似物的合成中间体。
• 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors
  申请人：Wyatt Paul Graham

  公开号：US20090012124A1

  公开（公告）日：2009-01-08

  The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.

  本发明提供了4-(2,6-二氯苯甲酰氨基)-1H-吡唑-3-羧酸哌啶-4-酰胺的酸加成盐及其晶体，所述盐是与甲磺酸、乙酸及其混合物选择的酸形成的。还提供了4-(2,6-二氯苯甲酰氨基)-1H-吡唑-3-羧酸哌啶-4-酰胺盐的新用途，制备4-(2,6-二氯苯甲酰氨基)-1H-吡唑-3-羧酸哌啶-4-酰胺及其盐和新的化学中间体的过程。
• 4-(2, 6-Dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)-amide for the Treatment of Cancer
  申请人：Trewartha Gary

  公开号：US20090318500A1

  公开（公告）日：2009-12-24

  The invention provides the compound of formula (I) 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)-amide in a substantially crystalline form, therapeutic uses thereof and pharmaceutical compositions containing the crystalline compound. The invention also provides novel pharmaceutical formulations containing 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)-amide and novel processes for preparing the compound.

  本发明提供了公式（I）4-（2,6-二氯苯甲酰氨基）-1H-吡唑-3-羧酸（1-甲磺酰基哌啶-4-基）-酰胺的晶体形式，其治疗用途和含有该晶体化合物的制药组合物。本发明还提供了包含4-（2,6-二氯苯甲酰氨基）-1H-吡唑-3-羧酸（1-甲磺酰基哌啶-4-基）-酰胺的新型制药配方和制备该化合物的新型工艺。
• 4-(2,6-DICHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID PIPERIDIN-4-YLAMIDE ACID ADDITION SALTS AS KINASE INHIBITORS
  申请人：WYATT Paul Graham

  公开号：US20110274616A1

  公开（公告）日：2011-11-10

  The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.

  本发明提供了4-(2,6-二氯苯甲酰氨基)-1H-吡唑-3-羧酸哌啶-4-酰胺的酸加成盐及其晶体，该盐是与甲磺酸、乙酸及其混合物中选择的酸形成的。此外，还提供了4-(2,6-二氯苯甲酰氨基)-1H-吡唑-3-羧酸哌啶-4-酰胺盐的新用途，制备4-(2,6-二氯苯甲酰氨基)-1H-吡唑-3-羧酸哌啶-4-酰胺及其盐和新的化学中间体的方法。
• TROPOMYOSIN-RELATED KINASE INHIBITORS
  申请人：PFIZER INC

  公开号：US20150322043A1

  公开（公告）日：2015-11-12

  The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

  本发明涉及公式I化合物及其药学上可接受的盐，其中取代基如本文所述，并且它们在医学上的应用，特别是作为TrkA拮抗剂。