1-ethyl-2-methyl-pentylamine | 35399-84-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-ethyl-2-methyl-pentylamine
• 英文别名: 3-Amino-4-methyl-heptan；1-Aethyl-2-methyl-pentylamin；1-Ethyl-2-methylpentylamine；4-methylheptan-3-amine
• CAS: 35399-84-9
• 化学式: C₈H₁₉N
• 分子量: 129.246
• InChiKey: AATYZZMKXORGOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-乙基-3-甲基己酰胺 在 alkaline hypobromite 作用下， 生成 1-ethyl-2-methyl-pentylamine
  参考文献：
  名称：

  Rohrmann; Shonle, Journal of the American Chemical Society, 1944, vol. 66, p. 1517,1519

  摘要：

  DOI：

文献信息

• New Simple Polymeric Supports with Hydrazone Linkers for Solid-Phase Synthesis of Ketones and Primary Amines
  作者：Ryszard Lazny、Aneta Nodzewska、Karol Wolosewicz

  DOI：10.1055/s-2003-42483

  日期：——

  The preparation of new solid supports with hydrazine anchoring groups and their application to solid-phase synthesis of ketones and primary amines are described. The supports were used for immobilization of ketones, 4-tert-butylcyclohexanone, pentan-3-one, acetone, N-methylpiperidone, N-benzylpiperidone, and tropinone in the form of their hydrazones. The polymer-supported hydrazones were subjected to deprotonation/alkylation procedure (LDA/RX) once or twice. The resulting alkylated products were cleaved off the solid support on treatment with trifluoroacetic acid in tetrahydrofuran providing α-alkylated or α,α′-bisalkylated ketones or were subjected to reductive cleavage with borane in tetrahydrofuran to give β-alkylated or β,β′-bisalkylated primary amines.

  本文描述了带有肼固定基团的新型固体载体的制备及其在酮和伯胺固相合成中的应用。这些载体用于酮类的固定化，包括4-叔丁基环己酮、戊-3-酮、丙酮、N-甲基哌啶酮、N-苄基哌啶酮和托品酮，形成它们的腙形式。聚合物支持的腙经过一次或两次的去质子化/烷基化过程（LDA/RX）。所得的烷基化产物在四氢呋喃中用三氟乙酸处理后从固体载体上脱离，生成α-烷基化或α,α′-双烷基化酮，或在四氢呋喃中用硼烷进行还原裂解，得到β-烷基化或β,β′-双烷基化伯胺。
• [EN] 3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS<br/>[FR] UTILISATION DE COMPOSES HETEROARYLES A SUBSTITUTION 3-ALKYLIDENEHYDRAZINO EN TANT QU'ACTIVATEURS DU RECEPTEUR DE LA THROMBOPOIETINE
  申请人：NISSAN CHEMICAL IND LTD

  公开号：WO2004108683A1

  公开（公告）日：2004-12-16

  A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14; aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13, SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10; alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14; aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

  化合物的结构式（1）如下：其中A是氮原子或CR4，B是氧原子、硫原子或NR9（但当A是氮原子时，B不是NH），R1是C2-14芳基，L1是键，CR10R11、氧原子、硫原子或NR12，X是OR13、SR13或NR14NR15，R2是氢原子、甲酰基、C1-10烷基或类似物，L2是键或类似物，L3是键，CR17R18、氧原子、硫原子或NR19，L4是键，CR20R21、氧原子、硫原子或NR22，Y是氧原子、硫原子或NR23，R3是C2-14芳基、化合物的互变异构体、前药或药学上可接受的盐或其溶剂化合物。
• ALPHA-SUBSTITUTED VINYLTIN COMPOUND
  申请人：Tatsuta Kuniaki

  公开号：US20090023939A1

  公开（公告）日：2009-01-22

  To provide α-substituted vinyltin useful for the search for function-developing substances such as pharmaceuticals/agrichemicals and functional materials and for the construction of a compound library. An α-substituted vinyltin compound represented by the formula (1), a tautomer or salt of the compound or a solvate thereof: R 2 CH═C(R 3 )Sn(R 1 ) 3 (1) wherein R 1 is a C 1-10 alkyl group, a C 2-14 aryl group or the like, R 2 is a C 2-14 aryl group, a C 2-9 heterocyclyl group, a C 3-10 cycloalkyl group or the like, and R 3 is a carbamoyl group, a thiocarbamoyl group, an isocyanate group, an isothiocyanate group, a formylamino group, a thioformylamino group, an isonitrile group, an urea group, a carbamate group or the like.

  提供α-取代的乙烯基锡，用于寻找功能发展物质，如药物/农药和功能材料，以及用于构建化合物库。由下式表示的α-取代的乙烯基锡化合物（1）或其互变异构体或盐或溶剂合物：R2CH═C(R3)Sn(R1)3（1）其中R1是C1-10烷基，C2-14芳基或类似物，R2是C2-14芳基，C2-9杂环基，C3-10环烷基或类似物，R3是氨基甲酰基，硫氨基甲酰基，异氰酸酯基，异硫氰酸酯基，甲酰氨基基，硫代甲酰氨基基，异腈基，脲基，氨基甲酸酯基或类似物。
• OPTICALLY ACTIVE DINICKEL COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE USING THE OPTICALLY ACTIVE DINICKEL COMPLEX AS CATALYST
  申请人：Shibasaki Masakatsu

  公开号：US20100298559A1

  公开（公告）日：2010-11-25

  There is provided a novel optically active dinickel complex and/or a production method of an optically active amine by an asymmetric Mannich reaction using the dinickel complex as a catalyst. An optically active dinickel complex of Formula (I) or Formula (I′): [where R 0 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are each independently a hydrogen atom, a halogen atom, a C 1-10 alkyl group or a C 1-10 alkoxy group, etc., R 2 and R 3 together form, together with a benzene ring bonded to them, a naphthalene ring, etc. A novel production method of an optically active amine by an asymmetric Mannich reaction using the dinickel complex as a catalyst.

  提供了一种新型光学活性二镍配合物和/或使用该二镍配合物作为催化剂进行不对称Mannich反应制备光学活性胺的生产方法。公式（I）或公式（I′）的光学活性二镍配合物：[其中R0、R1、R2、R3、R4、R5、R6和R7分别独立地是氢原子、卤素原子、C1-10烷基或C1-10烷氧基等，R2和R3连同与它们结合的苯环形成萘环等。使用该二镍配合物作为催化剂，通过不对称Mannich反应制备光学活性胺的新型生产方法。
• HYDRAZIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR
  申请人：Miyaji Katsuaki

  公开号：US20090253751A1

  公开（公告）日：2009-10-08

  Compounds effective for preventing, treatment or improving diseases against which activation of the thrombopoietin receptor is effective are provided. A compound represented by the formula (I) (wherein R 1 , R 2 , R 3 , L 1 , L 2 , X and Y are defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

  提供了一种用于预防、治疗或改善激活血小板生成素受体有效对抗的疾病的化合物。该化合物由式(I)所表示（其中R1、R2、R3、L1、L2、X和Y在描述中被定义），该化合物的互变异构体、前药或药物可接受的盐或其溶剂化物。