3α-hydroxy-5α-<1,2-3H>prognan-20-one | 138309-83-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3α-hydroxy-5α-<1,2-3H>prognan-20-one
• CAS: 138309-83-8
• 化学式: C₂₁H₃₄O₂
• 分子量: 322.484
• InChiKey: AURFZBICLPNKBZ-QLKXVJCJSA-N

反应信息

• 作为产物：
  描述：

  <1,2-3H>progesterone 反应 40.0h， 生成 3α-hydroxy-5α-<1,2-3H>prognan-20-one
  参考文献：
  名称：

  Synthesis of a [l,2-3H]-labeled pregnanolone

  摘要：

  A method is described for the synthesis and purification of 3-alpha-hydroxy-5-alpha-[1,2-H-3]pregnan-20-one. [1,2-H-3]progesterone (55 Ci/mmol) was incubated with a homogenate of rat brain tissue. The product was purified by Sephadex chromatography and thin-layer chromatography. The identity and purity of the product were established by successive recrystallizations and high-performance liquid chromatography. A 34% portion of the starting material was converted to 3-alpha-hydroxy-5-alpha-[1,2-H-3]pregnan-20-one. The final radiopurity of 3-alpha-hydroxy-5-alpha-pregnan-20-one obtained from four independent preparations was 94% to 99%.

  DOI：

  10.1016/0039-128x(91)90010-s