2-Chloro-3-(4-methylpyridin-1-ium-1-yl)naphthalene-1,4-dione;chloride | 75220-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Chloro-3-(4-methylpyridin-1-ium-1-yl)naphthalene-1,4-dione;chloride
• CAS: 75220-99-4
• 化学式: C₁₆H₁₁ClNO₂*Cl
• 分子量: 320.175
• InChiKey: KVVJWBDGNUFFSP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.23
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  38
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Chloro-3-(4-methylpyridin-1-ium-1-yl)naphthalene-1,4-dione;chloride 以 氯仿 为溶剂， 反应 27.0h， 生成 2-methyl-12-(4'-pyridyl)naphth<2,3-b>indolizin-6,11-dione methoiodide
  参考文献：
  名称：

  Ayyangar, N. R.; Kolhe, P. Y.; Lugade, A. G., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 1, p. 24 - 28

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基吡啶 、 2,3-二氯-1,4-萘醌 以 乙醇 为溶剂， 反应 4.0h， 生成 2-Chloro-3-(4-methylpyridin-1-ium-1-yl)naphthalene-1,4-dione;chloride
  参考文献：
  名称：

  Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones

  摘要：

  Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones would be potent antifungal agents. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.092

文献信息

• Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones
  作者：Chung-Kyu Ryu、Joo Hee Yoon、Ae Li Song、Hyun Ah Im、Ji Young Kim、Aram Kim

  DOI：10.1016/j.bmcl.2011.10.092

  日期：2012.1

  Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones would be potent antifungal agents. (C) 2011 Elsevier Ltd. All rights reserved.
• Ayyangar, N. R.; Kolhe, P. Y.; Lugade, A. G., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 1, p. 24 - 28
  作者：Ayyangar, N. R.、Kolhe, P. Y.、Lugade, A. G.、Tilak, B. D.

  DOI：——

  日期：——