3-Methyl-1-nonylbenzo[f]benzotriazol-3-ium-4,9-dione;chloride | 1346458-57-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-Methyl-1-nonylbenzo[f]benzotriazol-3-ium-4,9-dione;chloride
• CAS: 1346458-57-8
• 化学式: C₂₀H₂₆N₃O₂*Cl
• 分子量: 375.898
• InChiKey: PTRKYPLLCBXCPO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.24
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-溴壬烷 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 96.0h， 生成 3-Methyl-1-nonylbenzo[f]benzotriazol-3-ium-4,9-dione;chloride
  参考文献：
  名称：

  Mode of action investigation for the antibacterial cationic anthraquinone analogs

  摘要：

  Reported previously by our group, we have developed a novel class of antibacterial cationic anthraquinone analogs with superb potency (MIC <1 mu g/mL) against Gram positive (G+) pathogens including Methicillin-resistant Staphylococcus aureus (MRSA). However, most of these compounds only manifest modest antibacterial activity against Gram negative (G-) bacteria. Further investigation on the antibacterial mode of action using fluorogenic dyes reveals that these compounds exert two different modes of action that account for the difference in their antibacterial profile. It was found that most of the compounds exert their antibacterial activity by disrupting the redox processes of bacteria. At high concentration, these compounds can also act as membrane disrupting agents. This information can help to design new therapeutics against various bacteria. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.08.107

文献信息

• Mode of action investigation for the antibacterial cationic anthraquinone analogs
  作者：Ka Yee Chan、Jianjun Zhang、Cheng-Wei Tom Chang

  DOI：10.1016/j.bmcl.2011.08.107

  日期：2011.11

  Reported previously by our group, we have developed a novel class of antibacterial cationic anthraquinone analogs with superb potency (MIC <1 mu g/mL) against Gram positive (G+) pathogens including Methicillin-resistant Staphylococcus aureus (MRSA). However, most of these compounds only manifest modest antibacterial activity against Gram negative (G-) bacteria. Further investigation on the antibacterial mode of action using fluorogenic dyes reveals that these compounds exert two different modes of action that account for the difference in their antibacterial profile. It was found that most of the compounds exert their antibacterial activity by disrupting the redox processes of bacteria. At high concentration, these compounds can also act as membrane disrupting agents. This information can help to design new therapeutics against various bacteria. (C) 2011 Elsevier Ltd. All rights reserved.