4-[3-(cyclopropyl)-2-methyl-1,1-dioxo-1,2-dihydro-1λ (6)-benzo[1,2,4]thiadiazin-7-yl]-1,4-diaza-bicyclo[3.2.2]nonane | 1290635-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 4-[3-(cyclopropyl)-2-methyl-1,1-dioxo-1,2-dihydro-1λ (6)-benzo[1,2,4]thiadiazin-7-yl]-1,4-diaza-bicyclo[3.2.2]nonane
• 英文别名: 3-Cyclopropyl-7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-methyl-1lambda6,2,4-benzothiadiazine 1,1-dioxide；3-cyclopropyl-7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-methyl-1λ6,2,4-benzothiadiazine 1,1-dioxide
• CAS: 1290635-91-4
• 化学式: C₁₈H₂₄N₄O₂S
• 分子量: 360.48
• InChiKey: RCARXZMUMMCJRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR<br/>[FR] DÉRIVÉS CONDENSÉS D'AZINE POUR LE TRAITEMENT DE MALADIES LIÉES AUX RÉCEPTEURS DE L'ACÉTYLCHOLINE
  申请人：ORGANON NV

  公开号：WO2011045258A1

  公开（公告）日：2011-04-21

  The present invention relates to a heterocyclic derivative of formula (I) wherein the variables are as defined in the specification or to a pharmaceutically acceptable salt or solvate thereof. The present invention further relates to pharmaceutical compositions comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of disorders mediated by nicotinic acetylcholine receptors, such as schizophrenia and Alzheimer's disease.

  本发明涉及式(I)的杂环衍生物，其中变量如规范中所定义，或其药用可接受盐或溶剂。本发明还涉及包含所述杂环衍生物的药物组合物，以及它们在治疗中的应用，例如在治疗或预防由尼古丁乙酰胆碱受体介导的疾病，如精神分裂症和阿尔茨海默病。
• HETEROCYCLIC DERIVATIVES
  申请人：Ratcliffe Paul David

  公开号：US20120208796A1

  公开（公告）日：2012-08-16

  The present invention relates to a heterocyclic derivative of formula (I) wherein the variables are as defined in the specification or to a pharmaceutically acceptable salt or solvate thereof. The present invention further relates to pharmaceutical compositions comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of disorders mediated by nicotinic acetylcholine receptors, such as schizophrenia and Alzheimer's disease.

  本发明涉及一种式子为(I)的杂环衍生物，其中变量如规范中定义，或其药学上可接受的盐或溶剂。本发明还涉及包括所述杂环衍生物的制药组合物及其在治疗中的应用，例如用于治疗或预防由尼古丁乙酰胆碱受体介导的疾病，如精神分裂症和阿尔茨海默病。
• CONDENSED AZINE-DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR
  申请人：Merck Sharp & Dohme B.V.

  公开号：EP2488520B1

  公开（公告）日：2015-09-02
• US8841289B2
  申请人：——

  公开号：US8841289B2

  公开（公告）日：2014-09-23