tert-butyl 2-[methyl(1-methylethyl)amino]-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate | 1151665-21-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: tert-butyl 2-[methyl(1-methylethyl)amino]-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
• 英文别名: tert-butyl 2-[methyl(propan-2-yl)amino]-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate
• CAS: 1151665-21-2
• 化学式: C₁₇H₂₇N₃O₂
• 分子量: 305.42
• InChiKey: FHEBLTNPWQHKKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  45.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2216023A1

  公开（公告）日：2010-08-11

  Provided are a condensed pyridine derivative having a serotonin 5-HT2C receptor activation action, a prophylactic or therapeutic agent for a lower urinary tract symptom, obesity and/or organ prolapse and the like containing the condensed pyridine derivative, a screening method for a substance that increases leak point pressure upon a rise in the intravesical pressure or a prophylactic or therapeutic drug for stress urinary incontinence, a prophylactic or therapeutic drug for cystoceles or enteroceles, containing a substance that activates serotonin 5-HT2C receptor, and a method of screening for a therapeutic drug for cystoceles or enteroceles, including increasing an intravesical pressure after bilateral transection of the hypogastric nerve and pudendal nerve of an animal, and measuring a closure response in the urethra, the rectum or the vagina observed at that time. A serotonin 5-HT2C receptor activator containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.

  提供了一种具有激活5-羟色胺5-HT2C受体作用的缩合吡啶衍生物，一种含有该缩合吡啶衍生物的下尿路症状、肥胖和/或器官脱垂等的预防或治疗药物，一种在膀胱内压升高时增加漏点压力的物质的筛选方法，或一种压力性尿失禁的预防或治疗药物、一种预防或治疗膀胱阴道炎或肠阴道炎的药物，含有一种激活5-羟色胺5-HT2C受体的物质，以及一种筛选膀胱阴道炎或肠阴道炎治疗药物的方法，包括在双侧横断动物的胃下神经和阴部神经后增加膀胱内压，并测量当时观察到的尿道、直肠或阴道的闭合反应。一种血清素 5-HT2C 受体激活剂，含有由式表示的化合物： 其中各符号如说明书中所定义，或其盐。
• Condensed pyridine derivate and use thereof
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2789338A2

  公开（公告）日：2014-10-15

  Described is a method of screening for a drug for the prophylaxis or treatment of cystoceles or enteroceles, comprising increasing an intravesical pressure after bilateral transection of the hypogastric nerve and pudendal nerve of an animal, and measuring a closure response in the urethra, the rectum or the vagina observed at that time.

  描述了一种筛选预防或治疗膀胱或肠瘘药物的方法，包括在双侧切断动物的下腹神经和阴部神经后增加膀胱内压，并测量当时观察到的尿道、直肠或阴道的闭合反应。