2-Aethyl-cyclohexanon-semicarbazon | 4971-17-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Aethyl-cyclohexanon-semicarbazon
• 英文别名: Semicarbazon von 2-Ethyl-cyclohexanon；2-Ethyl-cyclohexanon-semicarbazon；2-ethyl-cyclohexanone semicarbazone；[(2-Ethylcyclohexylidene)amino]urea
• CAS: 4971-17-9
• 化学式: C₉H₁₇N₃O
• 分子量: 183.253
• InChiKey: CJSGDEAKZZMHEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 2-Aethyl-cyclohexanon-semicarbazon
  参考文献：
  名称：

  Some 1,2-Dialkylcyclohexanes

  摘要：

  DOI：

  10.1021/ja01178a509

文献信息

• Tiffeneau; Tchoubar; Saiaslambert, Bulletin de la Societe Chimique de France, 1947, p. 445,448
  作者：Tiffeneau、Tchoubar、Saiaslambert

  DOI：——

  日期：——
• Oxidation of Alcohols with Ketones
  作者：Homer Adkins、Richard C. Franklin

  DOI：10.1021/ja01854a021

  日期：1941.9
• Vavon; Conia, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1946, vol. 223, p. 245
  作者：Vavon、Conia

  DOI：——

  日期：——
• Reactions to tick antitoxin serum and the role of atropine in treatment of dogs and cats with tick paralysis caused by Ixodes holocyclus: a pilot survey
  作者：RB ATWELL、FE CAMPBELL

  DOI：10.1111/j.1751-0813.2001.tb12980.x

  日期：2001.6

  Objective To determine the incidence and nature of adverse reactions of dogs and cats to tick antitoxin serum and to re‐evaluate the role of atropine in the treatment of tick paralysis.Design A retrospective questionnaire of veterinarians.Procedure Questionnaires were posted to 320 veterinarians in tick‐endemic regions of Australia. Questions referred to dogs and cats treated for tick paralysis over a period of three years: the number treated, treatment protocols and adverse systemic reactions to tick antitoxin serum. Ninety completed questionnaires were returned and responses analysed.Results Veterinarians reported that approximately 3% of dogs exhibited adverse reactions immediately following treatment with tick antitoxin serum. Eighteen percent of these reactions were described as anaphylaxis, with the remaining 82% attributed to the Bezold‐Jarisch reflex. Six percent of cats treated with tick antitoxin serum reacted adversely and the majority of reactions (63%) were ascribed to the Bezold‐Jarisch reflex. Atropine was used routinely by 10% of responding veterinarians in the treatment of dogs and cats with tick paralysis. A similar number of veterinarians used atropine only in selected cases. Most veterinarians (76%) reported that they never used atropine in the treatment of tick paralysis in either dogs or cats. Within the survey population, premedication with atropine reduced the number of Bezold‐Jarisch reactions following tick antitoxin administration approximately five‐fold in dogs and four‐fold in cats.Conclusions Data from this pilot survey indicate that more cats than dogs have adverse systemic reactions to tick antitoxin serum and that the majority of these reactions in both dogs and cats could be related to the Bezold‐Jarisch reflex. The number of reactions to tick antitoxin serum in dogs and cats could be significantly reduced by the routine use of atropine prior to administration of tick antitoxin serum.