2-(2-氨基乙基)喹唑啉-4(3H-)-酮 | 437998-07-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2-(2-氨基乙基)喹唑啉-4(3H-)-酮
• 中文别名: 2-(2-氨乙基)-3H-4-喹唑啉酮
• 英文名称: 2-(2-aminoethyl)quinazolin-4(3H)-one
• 英文别名: 2-(2-aminoethyl)-3H-quinazolin-4-one
• CAS: 437998-07-7
• 化学式: C₁₀H₁₁N₃O
• mdl: MFCD09864269
• 分子量: 189.21
• InChiKey: CDRQKHVKJNPNRY-UHFFFAOYSA-N

物化性质

• 密度：
  1.35±0.1 g/cm3 (20 ºC 760 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

文献信息

• Aminopyrimidine Kinase Inhibitors
  申请人：Baldino Carmen M.

  公开号：US20110152235A1

  公开（公告）日：2011-06-23

  Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway.

  揭示了化合物、含有这些化合物的药物组合物，以及这些化合物和组合物作为酪蛋白激酶1（例如CK1γ）、酪蛋白激酶2（CK2）、Pim 1、Pim2、Pim3、TGFβ途径、Wnt途径、JAK/STAT途径和/或mTOR途径调节剂的用途。还揭示了用于治疗或预防一系列治疗适应症的用途，至少部分原因是由于酪蛋白激酶1（例如CK1γ）、酪蛋白激酶2（CK2）、Pim 1、Pim2、Pim3、TGFβ途径、Wnt途径、JAK/STAT途径和/或mTOR途径的异常生理活性。
• [EN] 1,4-DICARBONYL-PIPERIDYL DERIVATIVES<br/>[FR] DÉRIVÉS DE 1,4-DICARBONYLE-PIPÉRIDYLE
  申请人：MERCK PATENT GMBH

  公开号：WO2017076484A1

  公开（公告）日：2017-05-11

  Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

  式I中Z、W、Q、R和Y具有权利要求1中指示的含义的化合物是坦克酶的抑制剂，可用于治疗癌症、心血管疾病、中枢神经系统损伤和不同形式的炎症等疾病。
• COMPOUND HAVING STAT3 INHIBITORY ACTIVITY AND USE THEREOF
  申请人：CYTUS H&B CO., LTD.

  公开号：US20200354327A1

  公开（公告）日：2020-11-12

  The present invention relates to a compound exhibiting STAT3 inhibitory activity, or a pharmaceutically acceptable salt, solvate or hydrate of the same, and pharmaceutical uses of these. The compounds of the present invention efficiently inhibit the abnormal activity of STAT3 associated with various diseases and thus can be usefully utilized for the prevention and treatment of various STAT3-related diseases associated with cancer, autoimmune diseases, inflammatory diseases and the like.

  本发明涉及一种具有STAT3抑制活性的化合物，或其药学上可接受的盐、溶剂或水合物，以及这些化合物的药物用途。本发明的化合物有效地抑制了与各种疾病相关的STAT3异常活性，因此可用于预防和治疗与癌症、自身免疫性疾病、炎症性疾病等相关的各种STAT3相关疾病。
• Imidazole-2,4-Dione Inhibitors of Casein Kinase 1
  申请人：Baldino Carmen M.

  公开号：US20120316155A1

  公开（公告）日：2012-12-13

  Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), the TGFβ pathway and/or the Wnt pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), the TGFβ pathway and/or the Wnt pathway.

  本发明涉及一些化合物，其中包括这些化合物的药物组合物，以及这些化合物和组合物作为酪氨酸激酶1（例如CK1γ）、TGFβ途径和/或Wnt途径的调节剂的用途。本发明还涉及用于治疗或预防一系列治疗适应症的用途，这些治疗适应症至少部分归因于酪氨酸激酶1（例如CK1γ）、TGFβ途径和/或Wnt途径的异常生理活动。
• 1,4-dicarbonyl-piperidyl derivatives
  申请人：Merck Patent GmbH

  公开号：US10570116B2

  公开（公告）日：2020-02-25

  Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

  式 I 的化合物 其中 Z、W、Q、R 和 Y 的含义如权利要求 1 所示，是 Tankyrase 的抑制剂，可用于治疗癌症、心血管疾病、中枢神经系统损伤和不同形式的炎症等疾病。