3-(3-Methoxy-phenyl)-1,2-dihydro-naphthalene | 33322-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(3-Methoxy-phenyl)-1,2-dihydro-naphthalene
• 英文别名: 3-(3-Methoxyphenyl)-1,2-dihydronaphthalene
• CAS: 33322-79-1
• 化学式: C₁₇H₁₆O
• 分子量: 236.313
• InChiKey: AZYOYBDWNADMAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(3-methoxyphenyl)-3,4-dihydronaphthalen-1(2H)-one 在 叠氮磷酸二苯酯 、 二异丁基氢化铝 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成 3-(3-Methoxy-phenyl)-1,2-dihydro-naphthalene
  参考文献：
  名称：

  Inhibitors of Acyl CoA:Cholesterol Acyltransferase

  摘要：

  Conformational restriction of previously disclosed acyclic diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4-Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the mo st potent ACAT inhibitor identified (IC50 = 0.04 mu M in an in vitro rat hepatic microsomal ACAT assay, ED(50) = 0.72 mg/kg/day in cholesterol-fed hamsters).

  DOI：

  10.1021/jm950833d

文献信息

• Kametani,T. et al., Chemical and pharmaceutical bulletin, 1971, vol. 19, p. 1150 - 1157
  作者：Kametani,T. et al.

  DOI：——

  日期：——
• Inhibitors of Acyl CoA:Cholesterol Acyltransferase
  作者：Wayne Vaccaro、Cindy Amore、Joel Berger、Robert Burrier、John Clader、Harry Davis、Martin Domalski、Tom Fevig、Brian Salisbury、Rosy Sher

  DOI：10.1021/jm950833d

  日期：1996.1.1

  Conformational restriction of previously disclosed acyclic diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4-Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the mo st potent ACAT inhibitor identified (IC50 = 0.04 mu M in an in vitro rat hepatic microsomal ACAT assay, ED(50) = 0.72 mg/kg/day in cholesterol-fed hamsters).