(+/-)-N-[1-(2-amino-3-methylbutyl)-4-piperidinyl]-3-[(2-methoxyethoxy)(6-methyl-2-pyridinyl)-methyl]-7-methyl-3H-imidazo[4,5-b]pyridin-2-amine | 1140053-31-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡嗪类
• 英文名称: (+/-)-N-[1-(2-amino-3-methylbutyl)-4-piperidinyl]-3-[(2-methoxyethoxy)(6-methyl-2-pyridinyl)-methyl]-7-methyl-3H-imidazo[4,5-b]pyridin-2-amine
• 英文别名: N-[1-(2-amino-3-methylbutyl)piperidin-4-yl]-3-[2-methoxyethoxy-(6-methylpyridin-2-yl)methyl]-7-methylimidazo[4,5-b]pyridin-2-amine
• CAS: 1140053-31-1
• 化学式: C₂₇H₄₁N₇O₂
• 分子量: 495.668
• InChiKey: LGHANUAZYINPCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1196409B1

  公开（公告）日：2004-02-04
• US6747028B1
  申请人：——

  公开号：US6747028B1

  公开（公告）日：2004-06-08
• US7179811B2
  申请人：——

  公开号：US7179811B2

  公开（公告）日：2007-02-20
• US7528149B2
  申请人：——

  公开号：US7528149B2

  公开（公告）日：2009-05-05
• [EN] RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS<br/>[FR] INHIBITEURS DE REPLICATION DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2001000612A2

  公开（公告）日：2001-01-04

  This invention concerns the compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes or stereochemically isomeric forms thereof wherein -a?1=a2-a3=a4¿- is a radical of formula -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- wherein each hydrogen atom may optionally be substituted; Q is a radical of formula (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8), wherein Alk is C¿1-6?alkanediyl; Y?1¿ is a bivalent radical of formula-NR2- or -CH(NR?2R4)-; X1 is NR4¿, S, S(=O), S(=O)¿2?, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR?5aR5b), CH¿2-NR?4 or NR4-CH¿2; X2 is a direct bond, CH¿2?, C(=O), NR?4, C¿1-4alkyl-NR?4, NR4-C¿1-4alkyl; t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R3; provided that when R3 is hydroxy or C¿1-6?alkyloxy, then R?3¿ can not replace a hydrogen atom in the α position relative to a nitrogen atom; G is substituted C¿1-10?alkanediyl wherein the substituent is attached via an oxygen atom; R?1¿ is an optionally substituted monocyclic heterocycle or aryl; R2 is hydrogen, formyl, C¿1-6?alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C3-7cycloalkyl or C1-10alkyl substituted with N(R?6)¿2 and optionally with another substituent; R3 is hydrogen, hydroxy, C¿1-6?alkyl, C1-6alkyloxy, arylC1-6alkyl or arylC1-6alkyloxy; R?4¿ is hydrogen, C¿1-6?alkyl or arylC1-6alkyl; R?5a, R5b, R5c and R5d¿ are hydrogen or C¿1-6?alkyl; or R?5a and R5b, or R5c and R5d¿ taken together form a bivalent radical of formula -(CH¿2?)s- wherein s is 4 or 5; R?6¿ is hydrogen, C¿1-4?alkyl, formyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl or C1-6alkyloxycarbonyl; aryl is optionally substituted phenyl; Het is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl; as respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and their use as a medicine.