N-(2-甲氧基乙基)环丙胺 | 178366-15-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(2-甲氧基乙基)环丙胺
• 英文名称: N-(2-methoxyethyl)cyclopropanamine
• CAS: 178366-15-9
• 化学式: C₆H₁₃NO
• mdl: MFCD09804887
• 分子量: 115.17
• InChiKey: FLGBPLJSLMGJAR-UHFFFAOYSA-N

物化性质

• 沸点：
  142.6±13.0 °C(Predicted)
• 密度：
  0.93±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE DERIVATIVES AND THEIR USE AS PHD INHIBITORS<br/>[FR] INHIBITEURS 6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE DE PHD
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2014160810A1

  公开（公告）日：2014-10-02

  The present invention provides compounds of formula (I) which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

  本发明提供了公式(I)的化合物，这些化合物可用作PHD的抑制剂，以及与HIF相关疾病的治疗方法，制备这些化合物及其中间体的药物组合物。
• FXA INHIBITORS WITH CYCLIC AMIDOXIME OR CYCLIC AMIDRAZONE AS P4 SUBUNIT, PROCESSES FOR THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS AND DERIVATIVES THEREOF
  申请人：Song Ho Young

  公开号：US20110112083A1

  公开（公告）日：2011-05-12

  The present invention relates to novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group or the pharmaceutically acceptable salts thereof can be effectively used for the treatment of thromboembolism and tumor as an anticoagulant based on the inhibition of factor Xa.

  本发明涉及具有环氨基羟肟或环氨基脒基团的新型噁唑烷酮衍生物，其药学上可接受的盐，制备方法以及包含它们的药物组合物。具有环氨基羟肟或环氨基脒基团的噁唑烷酮衍生物或其药学上可接受的盐可有效用于作为抗凝剂治疗血栓栓塞和肿瘤，基于对因子Xa的抑制。
• METHODS FOR TREATING HEPATITIS C
  申请人：KARP Gary M.

  公开号：US20110268698A1

  公开（公告）日：2011-11-03

  The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IBES activity.

  本发明提供了化合物、药物组合物以及使用这些化合物或组合物治疗病毒感染或影响病毒IBES活性的方法。
• AMINOPYRAZOLE AMIDE DERIVATIVE
  申请人：Horiuchi Yoshihiro

  公开号：US20110071289A1

  公开（公告）日：2011-03-24

  Disclosed is a compound represented by the formula (1) below or a pharmaceutically acceptable salt thereof, which is useful as an agent for prevention and/or treatment of diabetes and the like. (In the formula, R A and R B independently represent an optionally substituted alkyl group or the like; R C represents an optionally substituted alkyl group or the like; R D represents a hydrogen atom or the like; R E represents a hydrogen atom or the like; and R F represents a group selected from those represented by the formulae (G1) below: wherein one hydrogen atom serves as a bonding hand, or the like.)

  本发明涉及一种化合物，其化学式如下（1），或其药学上可接受的盐，可用作预防和/或治疗糖尿病等疾病的药剂。（在公式中，RA和RB分别独立表示可选取代的烷基或类似物；RC表示可选取代的烷基或类似物；RD表示氢原子或类似物；RE表示氢原子或类似物；RF表示从以下式（G1）中选取的基团：其中一个氢原子作为结合手或类似物。）
• INHIBITORS OF BRUTON'S TYROSINE KINASE
  申请人：CHEN Wei

  公开号：US20130018032A1

  公开（公告）日：2013-01-17

  Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.

  本文描述了激酶抑制剂化合物、合成这种抑制剂的方法，以及使用这种抑制剂治疗疾病的方法。此外，本文还描述了确定蛋白质（包括激酶）适当抑制剂的方法、测定和系统。