| 1142923-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1142923-32-7
• 化学式: C₂₅H₂₃NO₃
• 分子量: 385.463
• InChiKey: ZLWNPSTUDGHWEB-GOTSBHOMSA-N

物化性质

• 沸点：
  591.9±50.0 °C(predicted)
• 密度：
  1.212±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  在 溶剂黄146 作用下， 以 CH₃Cl 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (−)-Paroxetine

  摘要：

  A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-Paroxetine, a blockbuster drug, in only three steps. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.02.049