17-Hydroxy-21-[(1-oxopentyl)oxy]pregna-1,4-diene-3,11,20-trione | 627846-14-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17-Hydroxy-21-[(1-oxopentyl)oxy]pregna-1,4-diene-3,11,20-trione
• 英文别名: [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] pentanoate
• CAS: 627846-14-4
• 化学式: C₂₆H₃₄O₆
• 分子量: 442.5
• InChiKey: FMAHAXZPHNEYRH-YRWVPJTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  97.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] TAZAROTENE DERIVATIVES<br/>[FR] DÉRIVÉS DE TAZAROTÈNE
  申请人：STIEFEL LABORATORIES

  公开号：WO2011009023A1

  公开（公告）日：2011-01-20

  The presently described subject matter relates to new derivatives of tazarotene that also exhibit retinoid activity, pharmaceutical compositions comprising the derivatives, method of treating skin disorders with the pharmaceutical compositions, and process of making the derivatives.

  目前所描述的主题涉及到新的他扎罗汀衍生物，它们也表现出类视黄醇活性，包括这些衍生物的制药组合物，使用这些制药组合物治疗皮肤疾病的方法，以及制造这些衍生物的过程。
• TAZAROTENE DERIVATIVES
  申请人：Ge Xue

  公开号：US20120115909A1

  公开（公告）日：2012-05-10

  The presently described subject matter relates to new derivatives of tazarotene that also exhibit retinoid activity, pharmaceutical compositions comprising the derivatives, method of treating skin disorders with the pharmaceutical compositions, and process of making the derivatives.

  目前所述的主题涉及到塔扎罗汀的新衍生物，这些衍生物也表现出类视黄醇活性，包括这些衍生物的制药组合物、使用这些制药组合物治疗皮肤疾病的方法以及制备这些衍生物的过程。
• Therapeutic use of mitochondria and combined mitochondrial agent
  申请人：Children's Medical Center Corporation

  公开号：US10370458B2

  公开（公告）日：2019-08-06

  The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.

  本公开涉及包含分离线粒体或联合线粒体制剂的组合物，以及使用此类组合物治疗疾病的方法。
• Topical foam composition
  申请人：Loupenok Leon

  公开号：US10568859B2

  公开（公告）日：2020-02-25

  The present invention relates to a novel oil in water emulsion aerosol foam composition containing an active agent for the treatment of various chronic and acute skin conditions, particularly acne and psoriasis; and processes for preparing the emulsion aerosol foam compositions. In particular, the present invention relates to oil in water emulsion aerosol foam compositions containing a retinoid in the oil phase.

  本发明涉及一种新型水包油型乳液气溶胶泡沫组合物，其中含有一种用于治疗各种慢性和急性皮肤病，特别是痤疮和银屑病的活性剂；以及制备该乳液气溶胶泡沫组合物的工艺。本发明尤其涉及在油相中含有维甲酸的水包油乳剂气溶胶泡沫组合物。
• Topical formulation
  申请人：Davis Adrian

  公开号：US10828250B2

  公开（公告）日：2020-11-10

  A formulation for topical dermatological delivery of a medicinal or cosmeceutical or cosmetic active including a functional co-enhancer delivery system. The delivery system generally comprises a water-miscible solvent and C12 or C14 fatty acids or C14 alcohol in combination with a hydrocarbyl methyl siloxane emollient.

  一种用于皮肤局部给药的配方，包括一种功能性辅助增强剂给药系统。递送系统一般包括水溶性溶剂和 C12 或 C14 脂肪酸或 C14 醇，以及烃基甲基硅氧烷润肤剂。