3-(7-methoxy-2-oxo-2H-quinoxalin-1-ylmethyl)-azetidine-1-carboxylic acid tert-butyl ester | 1221275-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(7-methoxy-2-oxo-2H-quinoxalin-1-ylmethyl)-azetidine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 3-[(7-methoxy-2-oxoquinoxalin-1-yl)methyl]azetidine-1-carboxylate
• CAS: 1221275-86-0
• 化学式: C₁₈H₂₃N₃O₄
• 分子量: 345.398
• InChiKey: XYWOKUVRPWBHAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7-甲氧基喹噁啉-2(1h)-酮 、 3-(甲烷磺酰氧基甲基)氮杂丁烷-1-羧酸叔丁酯 以the second eluting compound was isolated as a yellow oil (700 mg, 35% yield)的产率得到3-(7-methoxy-2-oxo-2H-quinoxalin-1-ylmethyl)-azetidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Oxazolidinyl antibiotics

  摘要：

  本发明涉及式I的抗菌化合物，其中R1是烷氧基或卤素; U和V各自独立地是CH或N; 是键或不存在; W是CH或N或，当不存在时，W是CH2或NH，但U、V和W不全是N; A是键或CH2; R2是H或，如果A是CH2，则也可以是OH; m和n各自独立地是0或1; D是CH2或键; G代表苯基，该苯基在间位和/或对位上被一次或两次取代，取代基选择自烷基，(C1-C3)烷氧基和卤素，或G是G1或G2基团，其中Z1，Z2和Z3可以各自代表CH或N; X是N或CH，Q是O或S; 如果m和n各自为0，则理解A是CH2;以及这种化合物的盐。

  公开号：

  US08507478B2

文献信息

• OXAZOLIDINYL ANTIBIOTICS
  申请人：Actelion Pharmaceuticals Ltd

  公开号：EP2344485B1

  公开（公告）日：2017-03-22
• US8507478B2
  申请人：——

  公开号：US8507478B2

  公开（公告）日：2013-08-13
• [EN] OXAZOLIDINYL ANTIBIOTICS<br/>[FR] ANTIBIOTIQUES OXAZOLIDINYLE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2010041218A2

  公开（公告）日：2010-04-15

  The invention relates to antibacterial compounds of Formula (I) wherein R1 is alkoxy or halogen; U and V each independently are CH or N; "----" is a bond or is absent; W is CH or N or, when "----" is absent, W is CH2 or NH, with the proviso that U, V and W are not all N; A is a bond or CH2; R2 is H or, provided A is CH2, may also be OH; m and n each independently are 0 or 1; D is CH2 or a bond; G represents a phenyl group substituted once or twice in the meta and/or para position (s) by substituents selected from alkyl, (C1-C3)alkyl and halogen, or G is a group G1 or G2 wherein Z1, Z2 and Z3 may each represent CH or N; X is N or CH and Q is O or S; it being understood that if m and n each are 0, then A is CH2; and salts of such compounds.