1,1'-十二亚甲基二胍二氯化物 | 61167-43-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,1'-十二亚甲基二胍二氯化物
• 英文名称: 1,1'-Dodecamethylenediguanidinium dichloride
• 英文别名: diaminomethylidene-[12-(diaminomethylideneazaniumyl)dodecyl]azanium;dichloride
• CAS: 61167-43-9
• 化学式: C14H34Cl2N6
• 分子量: 357.4
• InChiKey: ADQIVYXONPZRCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.99
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• COMPOSITIONS COMPRISING SASP MODULATORS AND SENESCENCE ATTENUATORS AND USES THEREOF FOR MODULATING CELLULAR SENESCENCE
  申请人：RSEM, LIMITED PARTNERSHIP

  公开号：US20200056186A1

  公开（公告）日：2020-02-20

  Described herein are compositions and methods for modulating cellular senescence of a cell or induction of the senescence-associated secretory phenotype (SASP) in a cell. The methods generally comprise modulating the level or activity of IRE1a as a mean to control cellular senescence and induction of the SASP. Also described are methods for treating and preventing ocular vascular diseases comprising contacting cells in an eye of a subject with a biguanide compound and ophthalmic compositions comprising a biguanide compound.