N-[1]naphthyl-N'-(N-phenyl-benzimidoyl)-urea | 116713-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[1]naphthyl-N'-(N-phenyl-benzimidoyl)-urea
• 英文别名: N-[1]Naphthyl-N'-(N-phenyl-benzimidoyl)-harnstoff；N'-Phenyl-N-(naphthyl-(1)-carbamoyl)-benzamidin；(1Z)-1-[anilino(phenyl)methylidene]-3-naphthalen-1-ylurea
• CAS: 116713-39-4
• 化学式: C₂₄H₁₉N₃O
• 分子量: 365.434
• InChiKey: PPZCSSGYKDUSOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.74
• 重原子数：
  28.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.49
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N-[1]naphthyl-N'-(N-phenyl-benzimidoyl)-urea 、 (3Z)-1-naphthalen-1-yl-3-[(naphthalen-2-ylamino)-phenylmethylidene]urea 、 N,N-二甲基甲酰胺 生成 2-Hydroxy-4-phenylbenzochinazolin
  参考文献：
  名称：

  ROBEV, S. K., DOKL. BOLG. AN, 40,(1987) N 12, 41-44

  摘要：

  DOI：
• 作为产物：
  描述：

  N-苯基亚胺苄基氯 在 乙醚 作用下， 生成 N-[1]naphthyl-N'-(N-phenyl-benzimidoyl)-urea
  参考文献：
  名称：

  Fiber-Type Transitions and Satellite Cell Activation in Low-Frequency-Stimulated Muscles of Young and Aging Rats

  摘要：

  We examined satellite cell content and the activity of satellite cell progeny in tibialis anterior muscles of young (15 weeks) and aging (101 weeks) Brown Norway (BN) rats. after they were exposed for 50 days to a standardized and highly reproducible regime of chronic low-frequency electrical stimulation. Chronic low-frequency electrical stimulation was successful in inducing fast-to-slow fiber-type transformation, characterized by a 2.3-fold increase in the proportion of IIA fibers and fourfold and sevenfold decreases in the proportion of IID/X and IIB fibers in both young and aging BN rats. These changes were accompanied by a twofold increase in the satellite cell content in both the young and aging groups: satellite cell content reached a level that was significantly higher in the young group (p < .04). The total muscle precursor cell content (i.e., satellite cells plus progeny), however, did not differ between groups, because there was a greater number of satellite cell progeny passing through the proliferative and differentiative compartments of the aging group. The resulting 1.5-fold increase in myonuclear content was similar in the young and aging groups. We conclude that satellite cells and satellite cell progeny of aging BN rats possess an unaltered capacity to contribute to the adaptive response.

  DOI：

  10.1093/gerona/56.12.b510