ethyl 4-iodo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate | 1383377-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: ethyl 4-iodo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate
• 英文别名: ethyl 4-iodo-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxylate
• CAS: 1383377-77-2
• 化学式: C₁₀H₁₁IN₂O₂
• 分子量: 318.114
• InChiKey: JDOCGCJQRZTVPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl 4-chloro-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate hydochloride 在 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 72.0h， 以71%的产率得到ethyl 4-iodo-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate
  参考文献：
  名称：

  NOVEL FUSED PYRIDINE COMPOUNDS AS CASEIN KINASE INHIBITORS

  摘要：

  本发明揭示了化合物及其药用可接受的盐，其中该化合物具有Formula I的结构：以及其药用可接受的盐，其中X、Y、A、R4、n和R7如规范中定义。本发明还揭示了相应的药物组合物、治疗方法、合成方法和中间体。

  公开号：

  US20120157440A1

文献信息

• Fused pyridine compounds as casein kinase inhibitors
  申请人：Butler Todd W.

  公开号：US08536164B2

  公开（公告）日：2013-09-17

  Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, A, R4, n, and R7 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本文披露了化合物及其药用可接受的盐，其中化合物的结构公式为I，其药用可接受的盐如下：其中X、Y、A、R4、n和R7在说明书中有定义。还披露了相应的药物组合物、治疗方法、合成方法和中间体。
• SOLID SOLUTION INDUCING LAYER FOR WEAK EPITAXY GROWTH OF NON-PLANAR PHTHALOCYANINE
  申请人：YAN Donghang

  公开号：US20120153265A1

  公开（公告）日：2012-06-21

  The present invention relates to solid solution inducing layer for the preparation of weak epitaxial films of non-planar phthalocyanine and the thin film of non-planar phthalocyanine generated from the weak epitaxial growth on the solid solution inducing layer and organic thin film transistor based on the weak rpitaxy growth thin film of non-planar phthalocyanine. The solid solution inducing layer is prepared at certain substrate temperature by vapor co-deposition of any two inducing layer molecules presented by Formula I and Formula II. The solid solution inducing layer has uniformed structure, of which the lattice parameter and electronic structure can be controlled by adjusting the component proportion, the solid solution inducing layer can epitaxially grow a high quality thin film of non-planar phthalocyanine and fabricate high performance transistor device based on such epitaxial thin film.
• US8536164B2
  申请人：——

  公开号：US8536164B2

  公开（公告）日：2013-09-17
• US8598151B2
  申请人：——

  公开号：US8598151B2

  公开（公告）日：2013-12-03
• [EN] NOVEL FUSED PYRIDINE COMPOUNDS AS CASEIN KINASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS FUSIONNÉS DE PYRIDINE EN TANT QU'INHIBITEURS DE LA CASÉINE KINASE
  申请人：PFIZER

  公开号：WO2012085721A1

  公开（公告）日：2012-06-28

  Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, A, R4, n, and R7 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.