5-methyl-6,11-dihydro-5H-benz[2,3]azepino[5,6-c]indol-12-one | 1202749-60-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-methyl-6,11-dihydro-5H-benz[2,3]azepino[5,6-c]indol-12-one
• CAS: 1202749-60-7
• 化学式: C₁₇H₁₄N₂O
• 分子量: 262.311
• InChiKey: SWAJPBHBBQERRW-UHFFFAOYSA-N

物化性质

• 熔点：
  236-240 °C(Solvent: Hexane; Tetrahydrofuran)
• 沸点：
  401.2±24.0 °C(predicted)
• 密度：
  1.28±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  5-methyl-5a,6,11,12a-tetrahydro-5H-benz[2,3]azepino[5,6-c]indol-12-one 在 manganese(IV) oxide 作用下， 以 氯仿 为溶剂， 反应 1.0h， 以61%的产率得到5-methyl-6,11-dihydro-5H-benz[2,3]azepino[5,6-c]indol-12-one
  参考文献：
  名称：

  Reactions of 2-(Lithiomethyl)phenyl Isocyanides with Methyl 1-Methylindole-3-carboxylate: Flaborations of the Adducts to 5H-Benz[2,3]azepino[5,6-c]indol-12-one and 2,3’-Biindolyl Derivatives

  摘要：

  It has been found that when 2-(lithiomethyl)phenyl isocyanides were allowed to react with methyl 1-methylindole-3-carboxylate, the corresponding 1,4-and/or 1,2-adducts were obtained. The 1,4-adducts could be transformed into 6,11-dihydro-5H-benz[2,3]azepino[5,6-b]indol-12-ones derivatives by acid hydrolysis, followed by lactamization and subsequent dehydrozgenation. The transformation of the 1,2-adducts into 2,3'-biindolyls was accomplished by a sequential treatment with hydrochloric acid and aqueous sodium hydroxide.

  DOI：

  10.3987/com-09-11778