4-methyl-6-(((3R,4R)-4-((5-(4-methylpyridin-2-yl)pentyl)oxy)pyrrolidin-3-yl)methyl)pyridin-2-amine | 1387089-64-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-methyl-6-(((3R,4R)-4-((5-(4-methylpyridin-2-yl)pentyl)oxy)pyrrolidin-3-yl)methyl)pyridin-2-amine
• 英文别名: 4-Methyl-6-{[(3r,4r)-4-{[5-(4-Methylpyridin-2-Yl)pentyl]oxy}pyrrolidin-3-Yl]methyl}pyridin-2-Amine；4-methyl-6-[[(3R,4R)-4-[5-(4-methylpyridin-2-yl)pentoxy]pyrrolidin-3-yl]methyl]pyridin-2-amine
• CAS: 1387089-64-6
• 化学式: C₂₂H₃₂N₄O
• 分子量: 368.522
• InChiKey: ZWYPXJQSZOXLSP-NQIIRXRSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  73.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Selective Neuronal Nitric Oxide Synthase Inhibitors
  申请人：Silverman Richard B.

  公开号：US20120258513A1

  公开（公告）日：2012-10-11

  Compounds and related methods for selective inhibition of neuronal nitric oxide synthase over inducible and endothelial isoforms, such compounds as can provide reduced cationic character and enhanced bioavailability.
• US8557552B2
  申请人：——

  公开号：US8557552B2

  公开（公告）日：2013-10-15
• [EN] SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS SÉLECTIFS DE L'OXYDE NITRIQUE SYNTHASE NEURONAL
  申请人：UNIV NORTHWESTERN

  公开号：WO2012139043A2

  公开（公告）日：2012-10-11

  Compounds and related methods for selective inhibition of neuronal nitric oxide synthase over inducible and endothelial isoforms, such compounds as can provide reduced cationic character and enhanced bioavailability.