(2-Amino-1-cyclohexylethyl)dimethylamine | 923249-17-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2-Amino-1-cyclohexylethyl)dimethylamine
• 英文别名: 1-cyclohexyl-N,N-dimethylethane-1,2-diamine
• CAS: 923249-17-6
• 化学式: C₁₀H₂₂N₂
• mdl: MFCD08444516
• 分子量: 170.3
• InChiKey: SKVJPJNCPKDEAF-UHFFFAOYSA-N

物化性质

• 沸点：
  220.6±8.0 °C(Predicted)
• 密度：
  0.915±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES
  申请人：Merck Patent GmbH

  公开号：US20160168090A1

  公开（公告）日：2016-06-16

  The present invention relates to indole compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.

  本发明涉及吲哚化合物及其药用可接受的组合物，用作P2X7拮抗剂，用于治疗与P2X7相关的疾病。
• NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF
  申请人：Schann Stephan

  公开号：US20110288074A1

  公开（公告）日：2011-11-24

  The present invention provides new compounds with high affinity for adenosine A 2A receptors. It also provides antagonists of adenosine A 2A receptors and their use as medicaments for the treatment and/or prophylaxis of diseases and disorders where the partial or total inactivation of adenosine A 2A receptors signalling pathways could be beneficial such as Alzheimer's disease, Parkinson's disease, attention deficit and hyperactivity disorders (ADHD), Huntington's disease, neuroprotection, schizophrenia, anxiety and pain. The present invention further relates to pharmaceutical compositions containing such new compounds with high affinity for adenosine A 2A receptors and their use for the treatment and/or prophylaxis of diseases and disorders where the partial or total inactivation of adenosine A 2A receptors could be beneficial

  本发明提供了具有高亲和力的新化合物，可与腺苷A2A受体结合。它还提供了腺苷A2A受体的拮抗剂及其用作药物治疗和/或预防疾病和紊乱的方法，其中腺苷A2A受体信号通路的部分或全部失活可能是有益的，例如阿尔茨海默病，帕金森病，注意力缺陷和多动症（ADHD），亨廷顿病，神经保护，精神分裂症，焦虑和疼痛。本发明还涉及含有这种具有高亲和力的新化合物的制药组合物及其在部分或全部失活腺苷A2A受体可能有益的疾病和紊乱的治疗和/或预防中的使用。
• Indole derivatives and their use in neurodegenerative diseases
  申请人：Merck Patent GmbH

  公开号：US10323000B2

  公开（公告）日：2019-06-18

  The present invention relates to indole compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.

  本发明涉及作为 P2X7 拮抗剂和用于治疗 P2X7 相关疾病的吲哚化合物及其药学上可接受的组合物。
• INDOLE AND AZAINDOLES DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES
  申请人：Merck Patent GmbH

  公开号：EP3233841A1

  公开（公告）日：2017-10-25
• US9029393B2
  申请人：——

  公开号：US9029393B2

  公开（公告）日：2015-05-12