| 1000357-18-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• CAS: 1000357-18-5
• 化学式: C₁₃H₉ClN₂O₂
• 分子量: 260.68
• InChiKey: XFDOBVUTVRYKPO-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 3-氨基-1-丙醇 生成
  参考文献：
  名称：

  Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives

  摘要：

  Several 1,8-naphthyridine-3-carboxamide derivatives (8 - 23) were synthesized and tested for in vitro cytotoxicity against eight cancer cell lines and a normal cell line. Compound 12 exhibited high cytotoxicity (IC50=1.37 mu M) in HBL-100 ( breast) cell line while compounds 17 (IC50=3.7 mu M) and 22 (IC50=3.0 mu M) have shown high cytotoxicity in KB (oral) and SW-620 (colon) cell lines, respectively. The synthesized 1,8-naphthyridine-3-carboxamides were also evaluated for anti-inflammatory and myeloprotective activities, indicated by modulation in cytokine and chemokine levels secreted by dendritic cells. (c) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2007.08.006
• 作为产物：
  描述：

  7-methyl-4-oxo-1-prop-2-ynyl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 在 磺酰氯 作用下， 生成
  参考文献：
  名称：

  Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives

  摘要：

  Several 1,8-naphthyridine-3-carboxamide derivatives (8 - 23) were synthesized and tested for in vitro cytotoxicity against eight cancer cell lines and a normal cell line. Compound 12 exhibited high cytotoxicity (IC50=1.37 mu M) in HBL-100 ( breast) cell line while compounds 17 (IC50=3.7 mu M) and 22 (IC50=3.0 mu M) have shown high cytotoxicity in KB (oral) and SW-620 (colon) cell lines, respectively. The synthesized 1,8-naphthyridine-3-carboxamides were also evaluated for anti-inflammatory and myeloprotective activities, indicated by modulation in cytokine and chemokine levels secreted by dendritic cells. (c) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2007.08.006