6-Bromo-2-[3-[4-[(2-chlorophenyl)methyl]-1,2,4-triazol-4-ium-1-yl]propyl]benzo[de]isoquinoline-1,3-dione;bromide | 1316753-95-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 6-Bromo-2-[3-[4-[(2-chlorophenyl)methyl]-1,2,4-triazol-4-ium-1-yl]propyl]benzo[de]isoquinoline-1,3-dione;bromide
• CAS: 1316753-95-3
• 化学式: Br*C₂₄H₁₉BrClN₄O₂
• 分子量: 590.701
• InChiKey: IRUNOPSXZBFJBZ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.48
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-bromo-2-(3-bromopropyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione 在 四丁基溴化铵 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 6-Bromo-2-[3-[4-[(2-chlorophenyl)methyl]-1,2,4-triazol-4-ium-1-yl]propyl]benzo[de]isoquinoline-1,3-dione;bromide
  参考文献：
  名称：

  Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents

  摘要：

  Naphthalimide-derived azoles as a new type of antimicrobial agents were synthesized and evaluated for their efficiency in vitro against eight bacteria and two fungi by two fold serial dilution technique. Most title compounds exhibited good antimicrobial potency with low MIC values ranging from 1 to 16 mu g/mL. Notably, some synthesized compounds displayed comparable or even better antibacterial and antifungal activities against some tested strains than the reference drugs Orbifloxacin, Chloromycin and Fluconazole, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.042

文献信息

• Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents
  作者：Yi-Yi Zhang、Cheng-He Zhou

  DOI：10.1016/j.bmcl.2011.05.042

  日期：2011.7

  Naphthalimide-derived azoles as a new type of antimicrobial agents were synthesized and evaluated for their efficiency in vitro against eight bacteria and two fungi by two fold serial dilution technique. Most title compounds exhibited good antimicrobial potency with low MIC values ranging from 1 to 16 mu g/mL. Notably, some synthesized compounds displayed comparable or even better antibacterial and antifungal activities against some tested strains than the reference drugs Orbifloxacin, Chloromycin and Fluconazole, respectively. (C) 2011 Elsevier Ltd. All rights reserved.