N-(2-hydroxyethyl)-1H-imidazole-5-carboxamide | 1493308-12-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-hydroxyethyl)-1H-imidazole-5-carboxamide
• CAS: 1493308-12-5
• 化学式: C₆H₉N₃O₂
• 分子量: 155.15
• InChiKey: SRJMBXMOYJIPDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS<br/>[FR] COMPOSÉS HÉTÉROARYLIQUES TÉTRASUBSTITUÉS ET LEUR UTILISATION COMME MODULATEURS DE MDM2 ET/OU MDM4
  申请人：NOVARTIS AG

  公开号：WO2011023677A1

  公开（公告）日：2011-03-03

  The invention relates to tetra-substituted heteroarylic compounds of the formula (I) wherein X1, X3 and X4 are independently C or N, Y is C-H, N-H or N, wherein the total number of nitrogen atoms represented by X1, X3, X4 and Y is 1 or 2; rings A and B are independently selected from phenyl or pyridyl; R1, R4, R', R", n and m are as defined herein. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

  该发明涉及公式（I）的四取代杂芳基化合物，其中X1、X3和X4独立地为C或N，Y为C-H、N-H或N，其中由X1、X3、X4和Y表示的氮原子的总数为1或2；环A和环B独立地选自苯基或吡啶基；R1、R4、R'、R"、n和m如本文所定义。这些化合物适用于治疗由MDM2和/或MDM4的活性或其变体介导的疾病或疾病。
• NOVEL DIPHENYL-PIPERIDINE DERIVATE
  申请人：AstraZeneca UK Limited

  公开号：EP1202984A1

  公开（公告）日：2002-05-08
• [EN] NOVEL DIPHENYL-PIPERIDINE DERIVATE<br/>[FR] NOUVEAU DERIVE DE DIPHENYLE-PIPERIDINE
  申请人：ASTRAZENECA UK LTD

  公开号：WO2001005782A1

  公开（公告）日：2001-01-25

  The invention provides compounds of general formula (I) wherein R?1, R2, R3, R4¿, A, Q, U, V, W, X, Y and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions.