4-(6-amino-1-hydroxy-3-sulfo-[2]naphthylazo)-benzoic acid | 109155-06-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(6-amino-1-hydroxy-3-sulfo-[2]naphthylazo)-benzoic acid
• 英文别名: 4-(6-Amino-1-hydroxy-3-sulfo-[2]naphthylazo)-benzoesaeure；4-[(6-Amino-1-hydroxy-3-sulfonaphthalen-2-yl)diazenyl]benzoic acid
• CAS: 109155-06-8
• 化学式: C₁₇H₁₃N₃O₆S
• 分子量: 387.373
• InChiKey: KFJPOIKABNENIQ-UHFFFAOYSA-N

物化性质

• 密度：
  1.63±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  171
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  7-氨基-4-羟基-2-萘磺酸 生成 4-(6-amino-1-hydroxy-3-sulfo-[2]naphthylazo)-benzoic acid
  参考文献：
  名称：

  Pituitary carcinoma: Report of an exceptional case and review of the literature

  摘要：

  Pituitary carcinomas are exceptional tumors and constitute 0.1 to 0.2% of pituitary tumors. Their definition includes well-established criteria but distant metastasis is the hallmark required for diagnosis. We report the fourth case of gonadotropic pituitary carcinoma described in the literature. This case illustrates the dramatic outcome of these tumors. The most interesting feature of our case was the loss of differentiation with time, established by retrospective analysis of the primary tumor surgically treated 15 years earlier. Most of the previously reported cases exhibited a majority of adrenocoticotropin and non-functioning pituitary tumors. However, the frequency of non-functioning tumors seems smaller than previously believed. In the discussion, we stress the need to detect these very aggressive tumors as early as possible and identify treatments to improve the dramatic course of these carcinomas. (C) 2002, Editrice Kurtis.

  DOI：

  10.1007/bf03343963