4,5,6,7-四氢-3-(三氟甲基)-1H-吡唑并[3,4-c]吡啶 | 853784-21-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4,5,6,7-四氢-3-(三氟甲基)-1H-吡唑并[3,4-c]吡啶
• 英文名称: 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine
• CAS: 853784-21-1
• 化学式: C₇H₈F₃N₃
• mdl: MFCD11042747
• 分子量: 191.15
• InChiKey: USWUQQKHXVZMAO-UHFFFAOYSA-N

物化性质

• 沸点：
  281.8±35.0 °C(Predicted)
• 密度：
  1.391±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2933990090

文献信息

• [EN] ATX MODULATING AGENTS<br/>[FR] AGENTS DE MODULATION D'ATX
  申请人：BIOGEN MA INC

  公开号：WO2015188051A1

  公开（公告）日：2015-12-10

  Compounds of formula (I) can modulate the activity of autotaxin (ATX).

  式(I)的化合物可以调节自体税肽酶（ATX）的活性。
• 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
  申请人：Ashton T Wallace

  公开号：US20060069116A1

  公开（公告）日：2006-03-30

  The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
• ATX MODULATING AGENTS
  申请人：BIOGEN MA INC.

  公开号：US20170197960A1

  公开（公告）日：2017-07-13

  Compounds of formula (I) can modulate the activity of autotaxin (ATX).
• US7265128B2
  申请人：——

  公开号：US7265128B2

  公开（公告）日：2007-09-04
• [EN] 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES<br/>[FR] DERIVES D'ACIDE 3-AMINO-4-PHENYLBUTANOIQUE UTILISES COMME INHIBITEURS DE LA DIPEPTIDYL PEPTIDASE POUR LE TRAITEMENT OU LA PREVENTION DU DIABETE
  申请人：MERCK & CO INC

  公开号：WO2004064778A2

  公开（公告）日：2004-08-05

  The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.