(13S,17R,20R)-13,17-secodiacholest-13,17-cycloether | 140616-54-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (13S,17R,20R)-13,17-secodiacholest-13,17-cycloether
• CAS: 140616-54-2
• 化学式: C₂₇H₄₈O
• 分子量: 388.678
• InChiKey: NILFYTOGSJIZSO-MURXZMBNSA-N

反应信息

• 作为产物：
  描述：

  在 吡啶 、 sodium tetrahydroborate 、 三氯氧磷 作用下， 以 异丙醇 为溶剂， 反应 16.75h， 生成 (13S,17R,20R)-13,17-secodiacholest-13,17-cycloether
  参考文献：
  名称：

  Studies of the synthesis of biomarkers. X. Synthesis of 13,17-secodiacholestanes

  摘要：

  13,17-Secodiacholestanes (6) were synthesized from cholesterol (1) in six steps. The key intermediates, (20R)- and (20S)-diacholest-13(17)-enes (3a and 3b), underwent ozonization and reduction to provide (20R)- and (20S)-13,17-secodiacholesta-13,17-dione (5a and 5b), respectively. On Clemmensen reduction, the diones (5a and 5b) yielded the target molecule 6. The structure of an unknown biomarker was shown to be different from the proposed 6 by gas chromatographic/mass spectrometric comparison.

  DOI：

  10.1016/0039-128x(92)90031-4