4-Aminohexan-2-ol | 1565989-00-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-Aminohexan-2-ol
• CAS: 1565989-00-5
• 化学式: C₆H₁₅NO
• 分子量: 117.19
• InChiKey: FQXRRPAWODYRLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN
  申请人：Praxis Biotech LLC

  公开号：US20190185451A1

  公开（公告）日：2019-06-20

  Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.

  描述了用于调节成纤维细胞活化蛋白（FAP）的化合物和组合物。这些化合物和组合物可能被用作治疗疾病的治疗剂，包括高增殖性疾病。
• [EN] PHENOL COMPOUNDS ALS TOLL -LIKE RECEPTOR 7 AGONISTS<br/>[FR] COMPOSÉS PHÉNOL EN TANT QU'AGONISTES DU RÉCEPTEUR 7 DE TYPE TOLL
  申请人：ASTRAZENECA AB

  公开号：WO2012066335A1

  公开（公告）日：2012-05-24

  The invention concerns compounds of Formula (I): wherein R1, R2, R3 and Q are as defined in the description. The present invention also relates to processes for the preparation of such compounds, novel intermediates useful in the preparation of such compounds, pharmaceutical compositions containing them and their use as toll-like receptor 7 agonists.

  这项发明涉及式(I)的化合物：其中R1、R2、R3和Q如描述中所定义。本发明还涉及制备这类化合物的方法，制备这类化合物有用的新中间体，含有它们的药物组合物以及它们作为Toll样受体7激动剂的用途。
• [EN] AMINOALKOXYPHENYL COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE<br/>[FR] COMPOSÉS AMINOALCOXYPHÉNYLE ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES
  申请人：DAINIPPON SUMITOMO PHARMA CO

  公开号：WO2012067269A1

  公开（公告）日：2012-05-24

  The invention concerns compounds of Formula (I): (I) wherein n, m, p, R1 and R2 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, novel intermediates useful in the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of disease, for example cancer.

  这项发明涉及式(I)的化合物：(I) 其中n、m、p、R1和R2如描述中所定义。本发明还涉及制备这些化合物的过程，用于制备这些化合物的新型中间体，含有它们的药物组合物以及它们在治疗疾病（例如癌症）中的用途。
• [EN] BENZYLAMINE COMPOUNDS AS TOLL -LIKE RECEPTOR 7 AGONISTS<br/>[FR] COMPOSÉS DE BENZYLAMINE À TITRE D'AGONISTES DU RÉCEPTEUR TOLL-LIKE 7
  申请人：ASTRAZENECA AB

  公开号：WO2012066336A1

  公开（公告）日：2012-05-24

  The invention concerns compounds of Formula (I), and pharmaceutically acceptable salts thereof: where such compounds act as TLR7 agonists and at the same time show advantageous selectivity over TLR8 and hERG, wherein the variable groups R1, R2 and n are as defined herein. The invention also relates to methods for the preparation of such compounds and intermediates useful in the preparation thereof, to pharmaceutical compositions containing such compounds, to the use of such compounds in the preparation of medicaments, and to the use of such compounds in the treatment of conditions mediated by TLR7, such as allergic diseases, autoimmune diseases, viral diseases and, in particular, cancer.

  该发明涉及式（I）的化合物及其药用盐：其中这些化合物作为TLR7激动剂，同时在TLR8和hERG上表现出有利的选择性，其中变量基团R1、R2和n如本文所定义。该发明还涉及制备这种化合物的方法和在制备中有用的中间体，含有这种化合物的药物组合物，利用这种化合物制备药物以及利用这种化合物治疗由TLR7介导的疾病，如过敏性疾病、自身免疫疾病、病毒性疾病，特别是癌症。
• Thermosetting molding and expansion-forming compositions
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0612777A2

  公开（公告）日：1994-08-31

  Provided by the present invention as molding and expansion-forming compositions having excellent properties are thermosetting molding compositions comprising an amino resin and a reinforcing material and thermosetting expansion-forming composition comprising the amino resin, an emulsifier, a foaming agent and a curing agent. The amino resin has been obtained by reacting a specific diguanamine, led by 2,5/2,6-bis (4,6-diaminol-1,3,5-triazin-2-yl)bicyclo[2.2.1]heptane or 1,3/1,4-bis(4,6-diaminol-1,3,5-triazin-2-yl)cyclohoezane, or a derivative thereof with an aldehydeh.

  本发明提供的具有优异性能的模塑和膨胀成形组合物是由氨基树脂和增强材料组成的热固性模塑组合物，以及由氨基树脂、乳化剂、发泡剂和固化剂组成的热固性膨胀成形组合物。氨基树脂是由特定的二胍胺（以 2,5/2,6-双(4,6-二氨基醇-1,3,5-三嗪-2-基)双环[2.2.1]庚烷或 1,3/1,4-双(4,6-二氨基醇-1,3,5-三嗪-2-基)环噻嗪或其衍生物为首）与醛反应而得。