5-[(3S)-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-(2-methylphenyl)-2,5-dioxo-1,4-benzodiazepin-1-yl]valeric acid | 794507-09-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-[(3S)-3-(4-chlorophenyl)-4-[(R)-1-(4-chlorophenyl)ethyl]-7-(2-methylphenyl)-2,5-dioxo-1,4-benzodiazepin-1-yl]valeric acid
• 英文别名: 5-[(3S)-3-(4-chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-7-(2-methylphenyl)-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid
• CAS: 794507-09-8
• 化学式: C₃₅H₃₂Cl₂N₂O₄
• 分子量: 615.556
• InChiKey: DFJDNIPBFMVZAY-NHRFMIRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  77.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED 1,4-DIAZEPINES AND USES THEREOF<br/>[FR] 1,4-DIAZEPINES SUBSTITUEES ET LEURS UTILISATIONS
  申请人：DIMENSIONAL PHARM INC

  公开号：WO2004096134A2

  公开（公告）日：2004-11-11

  The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I as defined herein, with R 1 to R 8 and X as defined herein or a solvate, hydrate or pharmaceutically acceptable salt thereof.