trans-4-Aminocyclohexanolacetat-hydrochlorid | 61367-37-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: trans-4-Aminocyclohexanolacetat-hydrochlorid
• CAS: 61367-37-1
• 化学式: C₈H₁₅NO₂*ClH
• 分子量: 193.674
• InChiKey: UJLZFPLEBIWJIR-KMMPGQJCSA-N

物化性质

• 溶解度：
  溶于水;二甲基亚砜

反应信息

• 作为反应物：
  描述：

  氯乙基异氰酸酯 、 trans-4-Aminocyclohexanolacetat-hydrochlorid 在 三乙胺 作用下， 生成 Acetic acid 4-[3-(2-chloro-ethyl)-ureido]-cyclohexyl ester
  参考文献：
  名称：

  Synthesis of analogs of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents

  摘要：

  The superior activity of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis-trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans-3-methylcyclohexyl, cis-2-methyl-1,3-dithian-5-yl, cis- and trans-2-methyl-1,3-dithian-5-yl-tetraoxide, and 1-methylhexyl (open-chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but three analogues effected 50% cure rates at nontoxic doses, the open-chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans-4) isomers were, with one exception, as active as or, in four of the eight examples, somewhat more active than the corresponding axial-equatorial (cis-4) isomers. In this series, four of the five 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2-chloroethyl analogues.

  DOI：

  10.1021/jm00212a019

文献信息

• CARBAZOLE DERIVATIVES FOR ORGANIC ELECTROLUMINESCENCE DEVICES
  申请人：Jatsch Anja

  公开号：US20140225046A1

  公开（公告）日：2014-08-14

  The present invention describes carbazole derivatives formula (1), where the following applies to the symbols used: Y is on each occurrence, identically or differently, CR or N; X is selected from C(R1)2, O, S, PR1, P(═O)R1 or BR1; characterised in that at least one group R is present which stands, identically or differently on each occurrence, for a group of the following formula (2), and/or in that at least one group R1 is present which stands for a group of the following formula (3) or (4), in particular for use as triplet matrix materials in organic electroluminescent devices. The invention furthermore relates to a process for the preparation of the compounds according to the invention and to electronic devices comprising same.

  本发明描述了咔唑衍生物的公式（1），其中以下符号的含义如下：Y在每次出现时，相同或不同地为CR或N；X从C（R1）2，O，S，PR1，P（═O）R1或BR1中选择；其特征在于至少存在一个R基团，该基团在每次出现时相同或不同，代表以下公式（2）的基团，和/或至少存在一个R1基团，该基团代表以下公式（3）或（4）的基团，特别适用于有机电致发光器件中的三重态基质材料。此外，本发明还涉及一种制备本发明化合物的方法和包含其的电子设备。
• CARBAZOLDERIVATE FÜR ORGANISCHE ELEKTROLUMINESZENZVORRICHTUNGEN
  申请人：Merck Patent GmbH

  公开号：EP2758372B1

  公开（公告）日：2017-05-17
• MATERIALIEN FÜR ELEKTRONISCHE VORRICHTUNGEN
  申请人：Merck Patent GmbH

  公开号：EP2931698B1

  公开（公告）日：2017-09-13
• US9543528B2
  申请人：——

  公开号：US9543528B2

  公开（公告）日：2017-01-10
• US9818948B2
  申请人：——

  公开号：US9818948B2

  公开（公告）日：2017-11-14