(6,7-diethoxyquinazolinyl)-trimethylammonium chloride | 1150157-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (6,7-diethoxyquinazolinyl)-trimethylammonium chloride
• 英文别名: 6,7-diethoxy-4-quinazolinyltrimethylammonium chloride；(6,7-Diethoxyquinazolin-4-yl)-trimethylazanium;chloride
• CAS: 1150157-00-8
• 化学式: C₁₅H₂₂N₃O₂*Cl
• 分子量: 311.812
• InChiKey: NVVMERNNEDXKSI-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.37
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT
  申请人：Konkanchi Durga Prasad

  公开号：US20100261740A1

  公开（公告）日：2010-10-14

  The invention relates to substituted 4-(tetrazol-5-yl)-quinazoline derivatives of the formula-I, or pharmaceutically-acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of substituted 4-(tetrazol-5-yl)-quinazoline derivatives, to pharmaceutical compositions containing the compound and to its use in the manufacture of medicaments for the production of an anti-proliferative effect in a warm-blooded animal such as man.

  本发明涉及式-I的取代4-(四唑-5-基)-喹唑啉衍生物或其药学上可接受的盐，其具有抗增殖活性，如抗癌活性，并因此在治疗人或动物体的方法中有用。本发明还涉及制造取代4-(四唑-5-基)-喹唑啉衍生物的过程，含有该化合物的药物组合物，以及其用于制造用于在温血动物（如人）中产生抗增殖效应的药物的用途。