2,2-bis(aminomethyl)propan-1-ol | 203304-34-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2-bis(aminomethyl)propan-1-ol
• 英文别名: 2,2-bis(aminomethyl)-1-propanol；3-Amino-2-(aminomethyl)-2-methylpropan-1-ol
• CAS: 203304-34-1
• 化学式: C₅H₁₄N₂O
• mdl: MFCD19207296
• 分子量: 118.179
• InChiKey: DNVWZGIOTUNEMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  72.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  bis(di-μ-diethylamino-dimethylaluminium) 、 2,2-bis(aminomethyl)propan-1-ol 以 二氯甲烷 为溶剂， 以72%的产率得到
  参考文献：
  名称：

  Reactions of Diethylaminodimethylaluminum Dimer with the Tripodal Ligands CH₃C(CH₂NH₂)₂(CH₂OH) and CH₃C(CH₂NH₂)(CH₂OH)(CH₂SPh):  Crystal Structure of [AlMe₂]₃Al[CH₃C(CH₂NH)₂(CH₂O)]₂

  摘要：

  Reactions of diethylaminodimethylaluminum dimer, [Me2Al(mu-NEt2)](2), with the tripodal ligands 2,2-bis(aminomethyl)-1-propanol, CH3C(CH2NH2)(2)(CH2OH), and 2-aminomethyl-2-(thiophenylmethyl)-1-propanol, CH3C(CH2NH2)(CH2OH)(CH2SPh), have yielded a tetranuclear organoaluminum compound {[AlMe2](3)[CH3C(CH2NH)(2)(CH2O)](2)Al} (1) and a trinuclear compound (AlMe2)(2)AlMe[CH3C(CH2NH)(CH2O)(CH2SPh)] (2), respectively. Both compounds were characterized by H-1 and C-13 NMR data, IR, and mass and elemental analysis. Compound 1 was also characterized by single-crystal X-ray diffraction analysis. Compound 1 crystallized in a tetragonal space group P4(1)2(1)2 (No. 92), with cell parameters a = 10.238(2) Angstrom, c = 24.470(2) Angstrom, V = 2565(1) Angstrom(3), Z = 4, and R = 0.060. It appears that the central aluminum atom is surrounded by two tripodal ligands in an octahedral geometry, whereas the other three aluminum atoms act to bridge the two ligands. Compound 2 has a pentacoordinated aluminum center surrounded by two tripodal ligands and one methyl group. The sulfur atoms on the tripodal ligand were not coordinated to the central aluminum atom.

  DOI：

  10.1021/ic971084o
• 作为产物：
  描述：

  N,N'-(2-hydroxymethyl-2-methylpropane-1,3-diyl)bis(phthalimide) 在 氢氧化钾 作用下， 以 水 为溶剂， 反应 12.0h， 生成 2,2-bis(aminomethyl)propan-1-ol
  参考文献：
  名称：

  Cation-exchange chromatography and selective complexation in the isolation of branched acyclic polyamines : Syntheses of Ethylidynetris(methanamine) [tame], 2,2-Bis(aminomethyl)propan-1-ol [hmmp], 4,4',4''-Ethylidynetris(3-azabutan-1-amine) [sen] and 5,5',5'-Ethylidynetris(4-azapentan-1-amine) [stn]

  摘要：

  大规模合成乙叉三(甲胺)* (tame) (tame)、2,2-双（氨基甲基）丙-1-醇* (hmmp)、4,4',4?-乙叉三羟甲基（3-氮杂丁烷-1-胺）* (sen) 和 5,5',5''-乙叉三羟甲基（4-氮杂戊烷-1-胺）* (stn) 的大规模合成。 (stn) 进行了描述。驯服剂、hmmp、sen 和 stn 的纯盐酸盐、 和 stn 的纯盐酸盐是直接从粗胺混合物中分离出来的。 酸化和阳离子交换色谱法。另一种方法是选择性络合[Co（己胺）] Cl3，然后进行 Zn/HCl 还原和阳离子交换色谱法。 Zn/HCl 还原和阳离子交换色谱法 分离出六胺 sen 和 stn 的六盐酸盐。 盐。与传统的溶剂萃取法和 传统的溶剂萃取法和（通常是热解）高真空蒸馏法相比，这些分离程序异常高效。 高真空蒸馏法相比，这些分离方法异常高效。

  DOI：

  10.1071/ch9830927

文献信息

• Cation-exchange chromatography and selective complexation in the isolation of branched acyclic polyamines : Syntheses of Ethylidynetris(methanamine) [tame], 2,2-Bis(aminomethyl)propan-1-ol [hmmp], 4,4',4''-Ethylidynetris(3-azabutan-1-amine) [sen] and 5,5',5'-Ethylidynetris(4-azapentan-1-amine) [stn]
  作者：RJ Geue、GH Searle

  DOI：10.1071/ch9830927

  日期：——

  Large-scale syntheses of ethylidynetris(methanamine)* (tame), 2,2-bis(aminomethyl)propan-1-ol* (hmmp), 4,4',4?-ethylidynetris(3-azabutan-1-amine)* (sen) and 5,5',5''-ethylidynetris(4-azapentan-1-amine)* (stn) are described. The pure hydrochloride salts of tame, hmmp, sen and stn are isolated directly from the crude amine mixtures by acidification and cation-exchange chromatography. Alternatively, selective complexation as [Co(hexamine)] Cl3 followed by Zn/HCl reduction and cation-exchange chromatography is used to isolate the hexamines sen and stn as their hexahydrochloride salts. These isolation procedures are exceptionally efficient compared with the conventional solvent extraction and (often pyrolytic) high-vacuum distillation methods.

  大规模合成乙叉三(甲胺)* (tame) (tame)、2,2-双（氨基甲基）丙-1-醇* (hmmp)、4,4',4?-乙叉三羟甲基（3-氮杂丁烷-1-胺）* (sen) 和 5,5',5''-乙叉三羟甲基（4-氮杂戊烷-1-胺）* (stn) 的大规模合成。 (stn) 进行了描述。驯服剂、hmmp、sen 和 stn 的纯盐酸盐、 和 stn 的纯盐酸盐是直接从粗胺混合物中分离出来的。 酸化和阳离子交换色谱法。另一种方法是选择性络合[Co（己胺）] Cl3，然后进行 Zn/HCl 还原和阳离子交换色谱法。 Zn/HCl 还原和阳离子交换色谱法 分离出六胺 sen 和 stn 的六盐酸盐。 盐。与传统的溶剂萃取法和 传统的溶剂萃取法和（通常是热解）高真空蒸馏法相比，这些分离程序异常高效。 高真空蒸馏法相比，这些分离方法异常高效。
• Reactions of Diethylaminodimethylaluminum Dimer with the Tripodal Ligands CH₃C(CH₂NH₂)₂(CH₂OH) and CH₃C(CH₂NH₂)(CH₂OH)(CH₂SPh):  Crystal Structure of [AlMe₂]₃Al[CH₃C(CH₂NH)₂(CH₂O)]₂
  作者：Mung-Dar Li、Chung-Cheng Chang、Michael Y. Chiang、Shiu-Tzung Liu

  DOI：10.1021/ic971084o

  日期：1998.4.1

  Reactions of diethylaminodimethylaluminum dimer, [Me2Al(mu-NEt2)](2), with the tripodal ligands 2,2-bis(aminomethyl)-1-propanol, CH3C(CH2NH2)(2)(CH2OH), and 2-aminomethyl-2-(thiophenylmethyl)-1-propanol, CH3C(CH2NH2)(CH2OH)(CH2SPh), have yielded a tetranuclear organoaluminum compound [AlMe2](3)[CH3C(CH2NH)(2)(CH2O)](2)Al} (1) and a trinuclear compound (AlMe2)(2)AlMe[CH3C(CH2NH)(CH2O)(CH2SPh)] (2), respectively. Both compounds were characterized by H-1 and C-13 NMR data, IR, and mass and elemental analysis. Compound 1 was also characterized by single-crystal X-ray diffraction analysis. Compound 1 crystallized in a tetragonal space group P4(1)2(1)2 (No. 92), with cell parameters a = 10.238(2) Angstrom, c = 24.470(2) Angstrom, V = 2565(1) Angstrom(3), Z = 4, and R = 0.060. It appears that the central aluminum atom is surrounded by two tripodal ligands in an octahedral geometry, whereas the other three aluminum atoms act to bridge the two ligands. Compound 2 has a pentacoordinated aluminum center surrounded by two tripodal ligands and one methyl group. The sulfur atoms on the tripodal ligand were not coordinated to the central aluminum atom.