1,8-二氮杂萘-3-羧酸,1,4-二氢-1,7-二甲基-4-羰基- | 13317-12-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 1,8-二氮杂萘-3-羧酸,1,4-二氢-1,7-二甲基-4-羰基-
• 英文名称: 1,7-dimethyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
• 英文别名: 1,7-dimethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid；1,7-Dimethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• CAS: 13317-12-9
• 化学式: C₁₁H₁₀N₂O₃
• mdl: MFCD18838960
• 分子量: 218.212
• InChiKey: FIQGPIHRUIEFQF-UHFFFAOYSA-N

物化性质

• 熔点：
  300 °C
• 沸点：
  404.6±45.0 °C(Predicted)
• 密度：
  1.391±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  70.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Modified iRNA agents
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US10676740B2

  公开（公告）日：2020-06-09

  The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety. e.g., cholesterol, is is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents.

  本发明涉及 iRNA 制剂，它最好包括一种单体，其中的核糖分子已被核糖以外的分子所取代。 加入这种单体可以调节加入其中的 iRNA 制剂的性质，例如，通过使用非核糖分子作为配体或其他实体（如亲脂分子，如胆固醇）直接或间接的连接点。 本发明还涉及制造和使用这种改性 iRNA 制剂的方法。
• MODIFIED iRNA AGENTS
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20190345498A1

  公开（公告）日：2019-11-14

  The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety. e.g., cholesterol, is is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents.
• US4182880A
  申请人：——

  公开号：US4182880A

  公开（公告）日：1980-01-08