(+/-) 3-[4-[2-(Phenothiazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid metformin salt | 446019-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (+/-) 3-[4-[2-(Phenothiazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid metformin salt
• 英文别名: 3-(Diaminomethylidene)-1,1-dimethylguanidine;2-ethoxy-3-[4-(2-phenothiazin-10-ylethoxy)phenyl]propanoic acid
• CAS: 446019-49-4
• 化学式: C₄H₁₁N₅*C₂₅H₂₅NO₄S
• 分子量: 564.709
• InChiKey: OWVXEGPPKDBTPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.37
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  176
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Pharmaceutically acceptable salts of tricyclic compounds
  申请人：DR. REDDY'S LABORATORIES LTD.

  公开号：US20020169146A1

  公开（公告）日：2002-11-14

  The present invention relates to pharmaceutically acceptable salts of compound of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. 1

  本发明涉及一般式(I)化合物的药物可接受盐、它们的衍生物、类似物、互变异构体、立体异构体、多晶形式、药学上可接受的溶剂化合物和含有它们的药学上可接受的组合物。
• US6897199B2
  申请人：——

  公开号：US6897199B2

  公开（公告）日：2005-05-24
• [EN] SALTS OF 3-4(4-(2-PHENOXAZIN- OR PHENOTHIAZIN-10-YL)ALKOXY)PHENYL)-2-ALKOXYPROPANOIC ACID DERIVATIVES WITH PPAR ACTIVITY FOR THE TREATMENT OF HYPERLIPIMEDIA AND TYPE II DIABETES<br/>[FR] DERIVES DE SELS D'ACIDE 3-4(4-(2-PHENOXAZIN- OU PHENOTHIAZIN-10-YL)ALKOXY)PHENYL)-2-ALCOXYPROPANOIQUE A ACTIVITE PPAR POUR LE TRAITEMENT DE L'HYPERLIPEMIE ET DU DIABETE DE TYPE II
  申请人：REDDY RESEARCH FOUNDATION

  公开号：WO2002062772A1

  公开（公告）日：2002-08-15

  The present invention relates to pharmaceutically acceptable salts of compound of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. Their derivatives, their analogs, their tautomeric forms, their steroisomers, their polymorphs, wherein R?1 and R2 may be same or different and independently represent hydrogen, halogen atom such as fluorine, chlorine, bromine or iodine; hydroxy, nitro, cyano or lower alkyl group; X represents a heteroatom selected from oxygen or sulfur; R?3¿ represents hydrogen or lower alkyl group; n is an integer ranging from 1-4; M represents a counter ion or a moiety which forms a pharmaceutically acceptable salt; p is an integer ranging from 1 to 2.