3α-Hydroxy-11,20-dioxo-pregnan | 16472-72-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3α-Hydroxy-11,20-dioxo-pregnan
• 英文别名: 3α-hydroxy-pregnane-11,20-dione；(3R,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one
• CAS: 16472-72-3
• 化学式: C₂₁H₃₂O₃
• 分子量: 332.483
• InChiKey: DUHUCHOQIDJXAT-SWPDNEGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Hypoallergenic steroidal anesthetic/hypnotic compositions
  申请人：INNOVET, INC.

  公开号：EP0399716B1

  公开（公告）日：1994-01-26
• INJECTABLE NEUROSTEROID FORMULATIONS CONTAINING NANOPARTICLES
  申请人：MARINUS PHARMACEUTICALS, INC.

  公开号：US20210128583A1

  公开（公告）日：2021-05-06

  The disclosure provides an injectable neurosteroid nanoparticle formulation comprising nanoparticles having a D50 of less than 2000 nm the nanoparticles comprising a neurosteroid of Formula I, where the variables R 1 -R 9 and X are defined herein and at least one surface stabilizer,. The surface stabilizer can be a polymeric surface stabilizer such as hydroxyethyl starch, dextran, or povidone. The injectable neurosteroid nanoparticle formulation can be an intravenous formulation. The disclosure also provides a lyophilized powder of the injectable neurosteroid nanoparticle formulation that can be reconstituted in an aqueous solution prior to administration. The disclosure provides injectable neurosteroid nanoparticle formulations and dry powders of such formulations that have been sterilized by ebeam irradiation. The disclosure provides a method of treating a patient having a seizure disorder, stroke, or traumatic brain injury, comprising administering an effective amount of the injectable neurosteroid nanoparticle formulation. The disclosure also provides combination methods in which the injectable neurosteroid nanoparticle formulation is a first active agent that is administered in combination with at least one additional active agent.