2-(4-fluorophenyl)-6-iodo-2,3-dihydroquinazolin-4(1H)-one | 1356820-24-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(4-fluorophenyl)-6-iodo-2,3-dihydroquinazolin-4(1H)-one
• 英文别名: 2-(4-fluorophenyl)-6-iodo-2,3-dihydro-1H-quinazolin-4-one
• CAS: 1356820-24-0
• 化学式: C₁₄H₁₀FIN₂O
• 分子量: 368.149
• InChiKey: WTKGCYOMVYQDAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-fluorophenyl)-6-iodo-2,3-dihydroquinazolin-4(1H)-one 、 2-甲基-3-丁炔-2-醇 在 copper(l) iodide 、 palladium 10% on activated carbon 、 三乙胺 、 三苯基膦 作用下， 以 乙醇 为溶剂， 反应 5.5h， 以82%的产率得到2-(4-fluorophenyl)-6-(3-hydroxy-3-methylbut-1-ynyl)-2,3-dihydroquinazolin-4(1H)-one
  参考文献：
  名称：

  Amberlyst-15 mediated synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones and their crystal structure analysis

  摘要：

  An efficient and clean method has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones using Amberlyst-15 as a recyclable catalyst. A variety of dihydroquinazolinones were prepared from 2-aminobenzamide and aldehydes under mild conditions in excellent yields. Further structure elaboration of one compound and the crystal structure analysis and hydrogen bonding patterns of the two compounds prepared by using this methodology is presented. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.023
• 作为产物：
  描述：

  2-氨基-5-碘苯甲酰胺 、 对氟苯甲醛 在 Amberlyst-15 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以96%的产率得到2-(4-fluorophenyl)-6-iodo-2,3-dihydroquinazolin-4(1H)-one
  参考文献：
  名称：

  Amberlyst-15 mediated synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones and their crystal structure analysis

  摘要：

  An efficient and clean method has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones using Amberlyst-15 as a recyclable catalyst. A variety of dihydroquinazolinones were prepared from 2-aminobenzamide and aldehydes under mild conditions in excellent yields. Further structure elaboration of one compound and the crystal structure analysis and hydrogen bonding patterns of the two compounds prepared by using this methodology is presented. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.023

文献信息

• One-pot synthesis of quinazolin-4(3H)-ones and2,3-dihydroquinazolin-4(1H)-ones utilizingN-(2-aminobenzoyl)benzotriazoles
  作者：İlbilge Merve ŞENOL、İlhami ÇELİK、İlker AVAN

  DOI：10.3906/kim-1906-50

  日期：——

  A convenient and efficient method has emerged for the one-pot synthesis of substituted quinazolin-4(3$H)$-ones and nonaromatic alkaloids. 2-Substituted quinazolin-4(3H)-ones, 2,3-disubstituted quinazolin-4(3$H)$-ones, and 2,3-dihydroquinazolin-4(1$H)$-ones were obtained at yields of 46% to 95% by a one-pot reaction of $N$-(2-aminobenzoyl) benzotriazoles with amines and orthoesters or aldehydes under

  一种方便，有效的方法已经出现，用于一锅合成取代的喹唑啉-4（3 $ H）$-one和非芳族生物碱。获得了2-取代的喹唑啉-4（3H）-一，2,3-二取代喹唑啉-4（3 $ H）$-一和2,3-二氢喹唑啉-4（1H）$-一。 $ N $-（2-氨基苯甲酰基）苯并三唑与胺和原酸酯或醛在无催化剂的条件下进行一锅反应，可将其提高到46％至95％。