3-(4-hydroxy-phenyl)-2-(2-methoxy-thiazol-4-yl)-4,5,6,6a-tetrahydro-3aH-pentalen-1-one | 1104633-79-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(4-hydroxy-phenyl)-2-(2-methoxy-thiazol-4-yl)-4,5,6,6a-tetrahydro-3aH-pentalen-1-one
• 英文别名: 3-(4-hydroxyphenyl)-2-(2-methoxy-1,3-thiazol-4-yl)-4,5,6,6a-tetrahydro-3aH-pentalen-1-one
• CAS: 1104633-79-5
• 化学式: C₁₈H₁₇NO₃S
• 分子量: 327.404
• InChiKey: NXLDEPWPHBFOKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  87.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NOVEL ESTROGEN RECEPTOR LIGANDS<br/>[FR] NOUVEAUX LIGANDS RÉCEPTEURS D'OETROGÈNES
  申请人：KAROBIO AB

  公开号：WO2009012954A1

  公开（公告）日：2009-01-29

  The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, wherein W, X, Y, Z, R1, R2, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are as defined in the specification. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.

  本发明提供了一种公式（I）的化合物，或其药用可接受的酯、酰胺、溶剂化物或盐，包括这样的酯或酰胺的盐，以及这样的酯、酰胺或盐的溶剂化物，其中W、X、Y、Z、R1、R2、R7、R8、R9、R10、R11、R12、R13、R14、R15和R16如说明书中所定义。本发明还提供了将此类化合物用于治疗或预防与雌激素受体活性相关的疾病或障碍相关状况的方法。
• Catalyst activators comprising expanded anions
  申请人：——

  公开号：US20010027161A1

  公开（公告）日：2001-10-04

  A compound useful as a catalyst activator corresponding to the formula: (A* +a ) b (Z*J* j ) −c d , wherein: A* is a cation of charge +a, Z* is an anion group of from 1 to 50 atoms not counting hydrogen atoms, further containing two or more Lewis base sites; J* independently each occurrence is a Lewis acid coordinated to at least one Lewis base site of Z*, and optionally two or more such J* groups may be joined together in a moiety having multiple Lewis acidic functionality, j is a number from 2 to 12 and a, b, c, and d are integers from 1 to 3, with the proviso that a×b is equal to c×d.

  一种有用的催化剂活化剂化合物，其化学式为：(A*+a)b(Z*J*j)−cd，其中：A*是带有+a电荷的阳离子，Z*是一个含有1至50个原子（不包括氢原子）的阴离子基团，进一步包含两个或更多的Lewis碱基位点；J*是独立的，每次出现时都是与Z*的至少一个Lewis碱基位点配位的Lewis酸，而且可选地，两个或更多这样的J*基团可以连接在一起，形成具有多个Lewis酸性功能的基团，j是从2到12的数字，a、b、c和d是从1到3的整数，但是a×b等于c×d。
• Delayed activity supported olefin polymerization catalyst compositions and method for making and using the same
  申请人：BP Chemical Limited

  公开号：US20040235646A1

  公开（公告）日：2004-11-25

  The invention provides supported catalyst and methods for making and using the same, which are characterized as employing organometallic Group 4-10 catalysts with specially selected dienes, which, when combined with a cocatalyst, result in a supported catast which has improved kinetic profiles in the gas polymerization process.

  本发明提供了支持催化剂及其制备和使用的方法，其特点在于采用了有机金属群4-10催化剂和特别选择的二烯烃，与协同催化剂结合后，在气相聚合过程中形成具有改进动力学特性的支持催化剂。
• NOVEL ESTROGEN RECEPTOR LIGANDS
  申请人：Apelqvist Theresa

  公开号：US20100210524A1

  公开（公告）日：2010-08-19

  The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, wherein W, X, Y, Z, R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 and R 16 are as defined in the specification. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.

  本发明提供了公式（I）的化合物或其药学上可接受的酯，酰胺，溶剂化物或盐，包括这种酯或酰胺的盐，以及这种酯，酰胺或盐的溶剂化物，其中W，X，Y，Z，R1，R2，R7，R8，R9，R10，R11，R12，R13，R14，R15和R16如规范中所定义。本发明还提供了这种化合物在治疗或预防与雌激素受体活性相关的疾病或疾病相关疾病的条件中的使用。
• Activator composition comprising aluminum compound mixture
  申请人：——

  公开号：US20010018396A1

  公开（公告）日：2001-08-30

  Compositions comprising: A) an aluminum compound corresponding to the formula AlAr f 3 , where Ar f is a fluorinated aromatic hydrocarbyl moiety of from 6 to 30 carbon atoms; B) an aluminum compound corresponding to the formula: AlAr f Q 1 Q 2 , or a dimer, adduct, or mixture thereof; where: Ar f is as previously defined; Q 1 is Ar f or a C 1-20 hydrocarbyl group, optionally substituted with one or more cyclohydrocarbyl, hydrocarbyloxy, hydrocarbylsiloxy, hydrocarbylsilylamino, hydrocarbylsilyl, silylhydrocarbyl, di(hydrocarbylsilyl)amino, hydrocarbylamino, di(hydrocarbyl)amino, di(hydrocarbyl)phosphino, or hydrocarbylsulfido groups having from 1 to 20 atoms other than hydrogen, or, further optionally, such substituents may be covalently linked with each other to form one or more fused rings or ring systems; and Q 2 is an aryloxy, arylsulfide or di(hydrocarbyl)amido group, optionally substituted with one or more hydrocarbyl, cyclohydrocarbyl, hydrocarbyloxy, hydrocarbylsiloxy, hydrocarbylsilylamino, hydrocarbylsilyl, silylhydrocarbyl, di(hydrocarbylsilyl)amino, hydrocarbylamino, di(hydrocarbyl)amino, di(hydrocarbyl)phosphino, or hydrocarbylsulfido groups having from 1 to 20 atoms other than hydrogen, or, further optionally such substituents may be covalently linked with each other to form one or more fused rings or ring systems, said Q 2 having from 3 to 20 atoms other than hydrogen; and the molar ratio of A):B) in the composition being from 0.1:1 to 10:1 are useful as activators for olefin polymerizations.

  包含以下成分的组合物 A) 与式 AlAr 相对应的铝化合物 f 3 其中 Ar f 是 6 至 30 个碳原子的氟化芳烃基； B) 符合以下式子的铝化合物AlAr f Q 1 Q 2 或二聚体、加合物或其混合物；其中 Ar f 如前定义； Q 1 是 Ar f 或一个 C 1-20 烃基，可任选被一个或多个环烃基、烃基氧基、烃基硅氧基、烃基硅烷基氨基、烃基硅烷基、硅烷基烃基、二(烃基硅烷基)氨基、烃基氨基、二(烃基)氨基取代、或二(烃基)氨基、二(烃基)氨基、二(烃基)膦、或烃基亚磺酸基团，这些基团除氢原子外还具有 1 至 20 个原子，或者，这些取代基可任选地相互共价连接，形成一个或多个融合环或环系统；和 Q 2 是芳氧基、芳硫基或二(烃基)氨基基团，可任选被一个或多个烃基、环氢烃基、烃比氧基、烃硅氧基、烃硅氨基、烃硅烷基、硅烷基氢烃基、二(烃硅基)氨基、烃氨基二(烃基)氨基、二(烃基)膦基或除氢原子外具有 1 至 20 个原子的烃基亚磺基，或者，这些取代基可进一步彼此共价连接，形成一个或多个融合环或环系统，所述 Q 2 具有 3 至 20 个除氢以外的原子；以及 组合物中 A):B) 的摩尔比为 0.1:1 至 10:1，可用作烯烃聚合的活化剂。