脱氧胆酸钠,一水 | 145224-92-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 脱氧胆酸钠,一水
• 中文别名: 脱氧胆酸钠一水合物；一水脱氧胆酸钠
• CAS: 145224-92-6
• 化学式: C24H42NaO5
• 分子量: 433.6
• InChiKey: HKLBTQUQYACMJN-WTCAICSISA-N

物化性质

• 熔点：
  >300°C
• 溶解度：
  H2O: 0.1 M ， 20 °C, 澄清，无色
• 最大波长(λmax)：
  λ: 260 nm Amax: 0.10λ: 280 nm Amax: 0.08

计算性质

• 辛醇/水分配系数(LogP)：
  3.27
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  78.8
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xn
• 危险类别码：
  R37,R22
• WGK Germany：
  3
• RTECS号：
  FZ2250000
• 海关编码：
  29181990
• 安全说明：
  S22,S26,S36/37/39

制备方法与用途

用途 

强大的溶解剂，用于溶解来自于人胎盘微粒体(microsomes)的雌激素合成酶(estrogen synthetase)

文献信息

• Native (telopeptide) placental collagen compositions
  申请人：Anthrogenesis Corporation

  公开号：EP2664341A2

  公开（公告）日：2013-11-20

  The present invention provides compositions comprising placental extracellular matrix, wherein said compositions comprise elastin and less than 0.01% by weight laminin or fibronectin. The invention further provides methods for preparing the compositions as well as their use for promoting wound healing, augmenting tissue repair, tissue replacement, treating dental defect or disease and replacement of lost, damaged or diseased gingival tissue.

  本发明提供了包含胎盘细胞外基质的组合物，其中所述组合物包含弹性蛋白和小于0.01%（重量百分比）的层粘连蛋白或纤维连接蛋白。本发明进一步提供了制备这些组合物的方法，以及它们在促进伤口愈合、增强组织修复、组织置换、治疗牙齿缺损或疾病以及置换脱落、受损或病变牙龈组织方面的用途。
• Collagen biofabric and methods of preparation and use therefor
  申请人：Anthrogenesis Corporation

  公开号：EP2700309A1

  公开（公告）日：2014-02-26

  The present invention relates to collagenous membranes produced from amnion, herein referred to as a collagen biofabric. The collagen biofabric of the invention has the structural integrity of the native non-treated amniotic membrane, i.e., the native tertiary and quaternary structure. The present invention provides a method for preparing a collagen biofabric from a placental membrane, preferably a human placental membrane having a chorionic and amniotic membrane, by decellularizing the amniotic membrane. In a preferred embodiment, the amniotic membrane is completely decellularized. The collagen biofabric of the invention has numerous utilities in the medical and surgical field including for example, blood vessel repair, construction and replacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures, and others. The benefits of the biofabric are, in part, due to its physical properties such as biomechanical strength, flexibility, suturability, and low immunogenicity, particularly when derived from human placenta.

  本发明涉及用羊膜生产的胶原蛋白膜，在此称为胶原蛋白生物布。本发明的胶原蛋白生物织物具有未经处理的原生羊膜的结构完整性，即原生的三级和四级结构。本发明提供了一种用胎盘膜制备胶原蛋白生物织物的方法，优选的胎盘膜是具有绒毛膜和羊膜的人类胎盘膜，制备方法是对羊膜进行脱细胞处理。在一个优选的实施方案中，羊膜是完全脱细胞的。本发明的胶原蛋白生物布料在医疗和外科领域有许多用途，例如包括血管修复、血管的构建和替换、肌腱和韧带替换、伤口包扎、外科移植物、眼科用途、缝合等。生物布料的优点部分是由于其物理特性，如生物力学强度、柔韧性、可缝合性和低免疫原性，特别是当其来源于人类胎盘时。
• COLLAGEN BIOFABRIC AND METHODS OF PREPARATION AND USE THEREFOR
  申请人：Anthrogenesis Corporation

  公开号：EP1575572A2

  公开（公告）日：2005-09-21
• REPAIR OF TYMPANIC MEMBRANE USING PLACENTA DERIVED COLLAGEN BIOFABRIC
  申请人：Anthrogenesis Corporation

  公开号：EP1901789A2

  公开（公告）日：2008-03-26
• HUMAN PLACENTAL COLLAGEN COMPOSITIONS, PROCESSES FOR THEIR PREPARATION, METHODS OF THEIR USE AND KITS COMPRISING THE COMPOSITIONS
  申请人：CELGENE CORPORATION

  公开号：EP1893249A2

  公开（公告）日：2008-03-05