ethyl N-(2-fluorophenyl)-N-[(4,5,7-trifluorobenzothiazol-2yl)methyl]succinamate | 162366-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: ethyl N-(2-fluorophenyl)-N-[(4,5,7-trifluorobenzothiazol-2yl)methyl]succinamate
• 英文别名: ethyl 4-[2-fluoro-N-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]anilino]-4-oxobutanoate
• CAS: 162366-66-7
• 化学式: C₂₀H₁₆F₄N₂O₃S
• 分子量: 440.418
• InChiKey: IAMCXBFPXFKADO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  87.7
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF
  申请人：Senju Pharmaceutical Co., Ltd.

  公开号：EP0647636A1

  公开（公告）日：1995-04-12

  A benzothiazole compound represented by general formula (I) and a pharmaceutically acceptable salt thereof wherein, R¹ represents halogen; R² and R³ represent each independently hydrogen or halogen; R⁴ represents hydrogen, halogen, lower alkyl, alkoxy or alkylmercapto; and R⁵ represents hydrogen or lower alkyl. The compound (I) and salt thereof have an aldose reductase inhibitor activity against mammals including human and is excellent in safety. Therefore they are useful as remedies for treating complications of diabetes, such as defective union of injured cornea, cataract, neurosis, retinopathy and nephropathy, in particular, cataract and neurosis.

  通式(I)代表的苯并噻唑化合物及其药学上可接受的盐 其中，R¹代表卤素；R²和R³各自独立地代表氢或卤素；R⁴代表氢、卤素、低级烷基、烷氧基或烷基巯基；R⁵代表氢或低级烷基。化合物(I)及其盐对哺乳动物（包括人类）具有醛糖还原酶抑制活性，并且安全性极佳。因此，它们可作为治疗糖尿病并发症的药物，如受伤角膜的缺陷结合、白内障、神经官能症、视网膜病变和肾病，尤其是白内障和神经官能症。
• US5532257A
  申请人：——

  公开号：US5532257A

  公开（公告）日：1996-07-02