2,3,4-trichloro-6-(2-benzthiazolyl)pyridine | 496849-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2,3,4-trichloro-6-(2-benzthiazolyl)pyridine
• 英文别名: 2-(4,5,6-Trichloropyridin-2-yl)-1,3-benzothiazole
• CAS: 496849-96-8
• 化学式: C₁₂H₅Cl₃N₂S
• 分子量: 315.61
• InChiKey: HWRFROPWIIQNTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  pyridine-2-dimethyliminochloride 、 2-氨基苯硫醇 在 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 2,3,4-trichloro-6-(2-benzthiazolyl)pyridine
  参考文献：
  名称：

  6-Aryl-4-aminopicolinates and their use as herbicides

  摘要：

  在6位上具有芳基或杂环芳基取代基的4-氨基吡啶甲酸及其胺和酸衍生物是有效的除草剂，展示了广泛的杂草控制谱。

  公开号：

  US20030114311A1

文献信息

• Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents
  申请人：Pfizer Inc.

  公开号：US20030236258A1

  公开（公告）日：2003-12-25

  The present invention relates to compounds of the formula 1 wherein R 2 , R 3 , R 6 and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).

  本发明涉及公式1的化合物，其中R2、R3、R6和A如规范中所定义，以及包含它们的药物组合物和它们的医药用途。本发明的化合物对于治疗或缓解哺乳动物（优选为人类、狗、猫和家畜）的炎症和其他与炎症相关的疾病，如骨关节炎、类风湿性关节炎、结肠癌和阿尔茨海默病非常有用。
• Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents
  申请人：——

  公开号：US20030119836A1

  公开（公告）日：2003-06-26

  The present invention relates to compounds of the formula 1 wherein R 1 , R 3 , R 5 , R 6 , and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).

  本发明涉及一种式子1的化合物，其中R1、R3、R5、R6和A如说明书中所定义，以及包含它们的制药组合物和它们的药用。本发明的化合物在哺乳动物（优选为人类、狗、猫和家畜）中治疗炎症和其他炎症相关疾病，如骨关节炎、类风湿性关节炎、结肠癌和阿尔茨海默病中有用。
• Sulfonyl heteroaryl triazoles as anti-inflammatory and analgesic agents
  申请人：Pfizer Products Inc.

  公开号：EP1273580A1

  公开（公告）日：2003-01-08

  The present invention relates to compounds of the formula wherein R1, R3, R5 and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).

  本发明涉及式如下的化合物 其中 R1、R3、R5 和 A 的定义见说明书，本发明涉及含有这些化合物的药物组合物及其药用用途。本发明的化合物可用于治疗哺乳动物（最好是人、狗、猫和家畜）的炎症和其他炎症相关疾病，如骨关节炎、类风湿性关节炎、结肠癌和阿尔茨海默病。
• Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents
  申请人：Pfizer Products Inc.

  公开号：EP1273576A1

  公开（公告）日：2003-01-08

  The present invention relates to compounds of the formula    wherein m, R1, R3, R4, and R5 are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).

  本发明涉及式如下的化合物 其中m、R1、R3、R4和R5的定义如说明书中所述，本发明涉及含有这些化合物的药物组合物及其药用用途。本发明的化合物可用于治疗或缓解哺乳动物（最好是人、狗、猫和家畜）的炎症和其他炎症相关疾病，如骨关节炎、类风湿性关节炎、结肠癌和阿尔茨海默病。
• Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents
  申请人：——

  公开号：US20030119835A1

  公开（公告）日：2003-06-26

  The present invention relates to compounds of the formula 1 wherein R 1 , R 3 , R 5 and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).

  本发明涉及式 1 的化合物 1 其中 R 1 , R 3 , R 5 和 A 在说明书中的定义，以及含有它们的药物组合物和它们的药用用途。本发明的化合物可用于治疗哺乳动物（最好是人、狗、猫和家畜）的炎症和其他炎症相关疾病，如骨关节炎、类风湿性关节炎、结肠癌和阿尔茨海默病。