2-(4-Oxoazetidin-2-yl)ethenyl acetate | 64066-58-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 英文名称: 2-(4-Oxoazetidin-2-yl)ethenyl acetate
• CAS: 64066-58-6
• 化学式: C₇H₉NO₃
• 分子量: 155.15
• InChiKey: OZTDSHAYQBLEAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-Oxoazetidin-2-yl)ethenyl acetate 、 在 钯 magnesium sulfate 作用下， 以 glass 为溶剂， 反应 0.17h， 以to provide 4-(2-acetoxyethyl)-azetidin-2-one (3.098 g) as a clear oil的产率得到4-(2-acetoxyethyl)-2-azetidinone
  参考文献：
  名称：

  Process for preparing carbapenem compounds

  摘要：

  本发明涉及6-和6,6-二取代-3-取代氨基-1-氮杂双环[3.2.0]庚-2-烯-7-酮-2-羧酸(I)：其中R.sup.1和R.sup.2是从氢，取代和未取代的：烷基，芳基和芳烷基等组成的群体中独立选择的；R'和R"分别从H，取代和未取代的烷基和芳烷基中独立选择，或者一起形成取代或未取代的环状基团。这些化合物及其药学上可接受的盐，酯和酰胺衍生物可用作抗生素。还公开了制备这些化合物的方法，包括包含这些化合物的制药组合物和在需要抗生素效果时给予化合物和组合物的治疗方法。

  公开号：

  US04707547A1
• 作为产物：
  描述：

  氯磺酰异氰酸酯 、 、 1-乙酰氧基-1,3-丁二烯 、 甲醚 、 以The reduction of 3 to provide the 4-(2-acetoxyethyl)-2-azetidinone (4)的产率得到4-(2-acetoxyethyl)-2-azetidinone
  参考文献：
  名称：

  Substituted azetidiones

  摘要：

  本发明涉及取代的氮杂四元酮（1），它们在制备1-卡巴-2-青霉烷-3-羧酸（I）中有用：##STR1## 其中R是氢或阻断基，而R.sup.1、R.sup.2和R.sup.3是独立选择自氢、烷基、芳基和芳烷基等组的。这种1-卡巴-2-青霉烷-3-羧酸及其药学上可接受的盐、酯和酰胺衍生物可用作抗生素。

  公开号：

  US04348320A1

文献信息

• 6-(1'-Hydroxyethyl)-3-substituted
  申请人：Merck & Co., Inc.

  公开号：US04424230A1

  公开（公告）日：1984-01-03

  Disclosed are 6-(1'-hydroxyethyl)-3-substituted amino-1-azabicyclo\x9b3.2.0!hept-2-en-7-one-2-carboxylic acids (I): \n' ##STR1## wherein R' and R" are independently selected from H, substituted and unsubstituted alkyl and aralkyl groups, or together form a substituted or unsubstituted cyclic group. Such compounds and their O- and carboxyl derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

  公开了6-(1'-羟乙基)-3-取代氨基-1-氮杂双环[3.2.0]庚-2-烯-7-酮-2-羧酸(I)：其中R'和R"独立选择自H、取代和未取代的烷基和芳基烷基，或一起形成取代或未取代的环状基团。这种化合物及其O-和羧基衍生物可用作抗生素。还公开了制备这种化合物的方法，包括这种化合物的制药组合物和在需要抗生素效应时给予这种化合物和组合物的治疗方法。
• Process for preparing carbapenem compounds
  申请人：Merck & Co., Inc.

  公开号：US04707547A1

  公开（公告）日：1987-11-17

  Disclosed are 6- and 6,6-disubstituted-3-substituted amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acids (I): ##STR1## wherein R.sup.1 and R.sup.2 are, inter alia, independently selected from the group consisting of hydrogen, substituted and unsubstituted: alkyl, aryl, and aralkyl; and R' and R" are independently selected from the group consisting of: H, substituted and unsubstituted alkyl and aralkyl, or together form a substituted or unsubstituted cyclic group. Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering compounds and compositions when an antibiotic effect is indicated.

  本发明涉及6-和6,6-二取代-3-取代氨基-1-氮杂双环[3.2.0]庚-2-烯-7-酮-2-羧酸(I)：其中R.sup.1和R.sup.2是从氢，取代和未取代的：烷基，芳基和芳烷基等组成的群体中独立选择的；R'和R"分别从H，取代和未取代的烷基和芳烷基中独立选择，或者一起形成取代或未取代的环状基团。这些化合物及其药学上可接受的盐，酯和酰胺衍生物可用作抗生素。还公开了制备这些化合物的方法，包括包含这些化合物的制药组合物和在需要抗生素效果时给予化合物和组合物的治疗方法。
• 3-Substituted
  申请人：Merck & Co., Inc.

  公开号：US04218463A1

  公开（公告）日：1980-08-19

  Disclosed are 3-substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids having the structure: ##STR1## wherein: R.sup.1 is hydrogen or acyl and R.sup.8 is, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

  本发明涉及3-取代硫-6-酰胺-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸，其结构为：##STR1##其中：R.sup.1为氢或酰基，R.sup.8是独立选择的氢、烷基、烯基、芳基和芳基烷基等。这些化合物及其药学上可接受的盐、酯和酰胺衍生物可用作抗生素。本发明还公开了制备这些化合物的方法，包括含有这些化合物的制药组合物以及在需要抗生素效果时，通过给予这些化合物和组合物的方法进行治疗。
• 6-Amido-1-carba-2-penem-3-carboxylic acid
  申请人：Merck & Co., Inc.

  公开号：US04218459A1

  公开（公告）日：1980-08-19

  Disclosed are 6-amido-1-carba-2-penem-3-carboxylic acids of the following structure: ##STR1## wherein R.sup.1 is hydrogen or acyl and R.sup.3 is, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

  本发明涉及以下结构的6-酰胺-1-卡巴-2-青霉烷-3-羧酸：##STR1## 其中R.sup.1为氢或酰基，R.sup.3为独立选择的氢，烷基，芳基和芳基烷基等物。这些化合物及其药学上可接受的盐，酯和酰胺衍生物可用作抗生素。本发明还涉及制备这些化合物的方法，包括这些化合物的制药组合物和在需要抗生素作用时给予这些化合物和组合物的治疗方法。
• 3-(2-Aminoethylthio)-6-amido-7-oxo-1-azabicyclo[3.2.0]-
  申请人：Merck & Co., Inc.

  公开号：US04224336A1

  公开（公告）日：1980-09-23

  Disclosed are 3-(2-aminoethylthio)-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxy lic acids having the structure: ##STR1## wherein R.sup.1 is hydrogen or acyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

  本发明涉及具有以下结构的3-(2-氨基乙硫基)-6-酰胺-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸：##STR1##其中R.sup.1为氢或酰基。这些化合物以及它们的药学上可接受的盐，酯和酰胺衍生物可用作抗生素。本发明还涉及制备这些化合物的方法，包含这些化合物的制药组合物以及在需要抗生素效果时，通过给予这些化合物和组合物的方法进行治疗。