The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also contained therein, the inactivation process comprising subjecting said composition to a virucidally effective amount of irradiation in the presence of (a) a mixture of a compound that quenches type I photodynamic reactions and a compound that quenches type II photodynamic reactions or (b) a bifunctional compound that is capable of quenching both type I and type II reactions, to thereby inactivate said virus while retaining functionality of said composition. The composition is advantageously subjected to the irradiation and the mixture of compounds or bifunctional compound in the presence of an irradiation sensitizer. Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation.
本发明涉及通过使
生物组成物中的细胞外或细胞内病原病毒失活而不造成细胞的重大破坏或失活,并且不会显著损失其中包含的易降解蛋白质或其他有价值的
生物组分的产品。失活过程包括将该组成物暴露于具有杀毒作用的辐射量,同时存在(a)一种淬灭I型光动力反应的化合物和一种淬灭II型光动力反应的化合物的混合物或(b)能够淬灭I型和II型反应的双功能化合物,以此失活病毒同时保留该组成物的功能性。该组成物有利地暴露于辐射和化合物混合物或双功能化合物的同时存在辐射敏化剂。此外,该过程可以有利地与另一种杀毒方法结合,以增强病毒失活效果。