3-(Aminomethyl)-3-methylpentane | 143689-09-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(Aminomethyl)-3-methylpentane
• 英文别名: 2-ethyl-2-methylbutan-1-amine
• CAS: 143689-09-2
• 化学式: C₇H₁₇N
• 分子量: 115.22
• InChiKey: HGGUWASRBGFLDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Imidazolothiazole compounds for the treatment of disease
  申请人：Bhagwat Shripad

  公开号：US20070232604A1

  公开（公告）日：2007-10-04

  Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

  提供了用于调节受体激酶活性以及用于治疗、预防或改善由受体激酶介导的一种或多种疾病或紊乱症状的化合物、组合物和方法。
• [EN] PREPARATION OF ISOHEXIDE-3,6-DICARBALDEHYDES AND ISOHEXIDE-3,6-DIMETHANAMINES<br/>[FR] PRÉPARATION D'ISOHEXIDE-3,6-DICARBALDÉHYDES ET D'ISOHEXIDE-3,6-DIMÉTHANAMINES
  申请人：ARCHER DANIELS MIDLAND CO

  公开号：WO2017105985A1

  公开（公告）日：2017-06-22

  Methods for synthesizing isohexide-3,6-dicarbaldehydes and/or isohexide-3,6-dimethanamines from the dehydration products of sugar alcohols (isohexides) and corresponding derivatives are described. The methods involve initially converting the -OH moieties of an isohexide into triflates using triflic anhydride at low temperatures, followed by a carbon-centered nitrile-for-triflate substitution, forming crystalline isohexide-3,6-dinitriles. The isohexide-3,6-dinitriles are then reacted with a reducing agent, such as a metal hydride, in an anhydrous organic solvent at very low temperatures to generate isohexide-3,6-dicarbaldehydes. In a subsequent reductive animation, the isohexide-3,6-dicarbaldehydes are first converted into corresponding diimines, which can be isolated, or then reduced to isohexide-3,6-dimethanamines.

  本文介绍了从糖醇（异己糖）的脱水产物及其衍生物中合成异己糖-3,6-二醛和/或异己糖-3,6-二甲胺的方法。该方法首先使用三氟乙酸酐在低温下将异己糖的-OH官能团转化为三氟甲烷磺酰基，然后进行碳中心的腈-三氟甲烷磺酰基取代反应，形成晶体异己糖-3,6-二腈。然后在无水有机溶剂中，使用金属氢化物等还原剂在极低温度下将异己糖-3,6-二腈还原生成异己糖-3,6-二醛。在随后的还原氨基化反应中，异己糖-3,6-二醛首先被转化为相应的二亚胺，可以被分离出来，或者被进一步还原为异己糖-3,6-二甲胺。
• BENZOBIS (THIADIAZOLE) DERIVATIVE, INK CONTAINING SAME, AND ORGANIC ELECTRONIC DEVICE USING SAME
  申请人：UBE Industries, Ltd.

  公开号：EP3048107A1

  公开（公告）日：2016-07-27

  The present invention relates to a benzobis(thiadiazole) derivative represented by the following general formula (1): wherein R1 represents a linear or branched alkyl group, or any one of the groups of the following formula (2): wherein R represents a linear or branched alkyl group; R2 represents a hydrogen atom; and R3 represents a hydrogen atom, a linear or branched alkyl group, or any one of the groups of the formula (2); with the proviso that at least one of R1 and R3 represents any one of the groups of the formula (2); and two R1 groups, two R2 groups, and two R3 groups may be the same as, or different from each other.

  本发明涉及一种由以下通式（1）表示的苯并双(噻二唑)衍生物： 其中 R1 代表直链或支链烷基，或下式（2）中的任一基团： 其中 R 代表直链或支链烷基； R2 代表氢原子 R3 代表氢原子、直链或支链烷基或下式（2）中的任一基团； 但条件是 R1 和 R3 中至少有一个代表式（2）中的任一基团；及 两个 R1 基团、两个 R2 基团和两个 R3 基团可以相同，也可以不同。
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP4016656A1

  公开（公告）日：2022-06-22

  An organometallic compound represented by Formula 1:         Formula 1     M1(Ln1)n1(Ln2)n2 wherein Ln1 is a ligand represented by Formula 1A, Ln2 is a ligand represented by Formula 1B, n1 is 0, 1, or 2, n2 is 1, 2, or 3, wherein CY1, CY2, CY3, R10, R20, R30, X1, X2, Y1 to Y8, and b10 to b30 are as described herein, and wherein * and *' each indicate a binding site to M1.

  由式 1 表示的有机金属化合物： 式 1 M1(Ln1)n1(Ln2)n2 其中 Ln1 是由式 1A 表示的配体，Ln2 是由式 1B 表示的配体，n1 是 0、1 或 2，n2 是 1、2 或 3、 其中 CY1、CY2、CY3、R10、R20、R30、X1、X2、Y1 至 Y8 和 b10 至 b30 如本文所述， * 和 *' 分别表示与 M1 结合的位点。
• Somatostatin modulators and uses thereof
  申请人：Crinetics Pharmaceuticals, Inc.

  公开号：US10875839B2

  公开（公告）日：2020-12-29

  Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

  本文描述了作为体生长抑素调节剂的化合物、制造此类化合物的方法、包含此类化合物的药物组合物和药剂，以及使用此类化合物治疗可受益于体生长抑素活性调节的病症、疾病或紊乱的方法。